TSHR and FN1

Number of citations of the paper that reports this interaction (PubMedID 11981027)
0

Data Source:
HPRD (in vivo)

		TSHR	FN1
Description		thyroid stimulating hormone receptor	fibronectin 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex	Extracellular Region Fibrinogen Complex Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Protease Binding Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity Identical Protein Binding Proteoglycan Binding Receptor Ligand Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Angiogenesis Regulation Of Protein Phosphorylation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Integrin-mediated Signaling Pathway Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Gene Expression Response To Muscle Activity Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Wound Healing Endothelial Cell Migration Positive Regulation Of Axon Extension Positive Regulation Of Fibroblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Monocyte Activation Neural Crest Cell Migration Involved In Autonomic Nervous System Development Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events	Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Fibronectin matrix formation Cell surface interactions at the vascular wall Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Interleukin-4 and Interleukin-13 signaling Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates PTK2 signaling Post-translational protein phosphorylation GPER1 signaling Attachment of bacteria to epithelial cells Signaling downstream of RAS mutants Signaling by RAF1 mutants ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells
Drugs		Thyrotropin alfa	Zinc Lanoteplase Ocriplasmin Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 33020668 32469254 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30578418) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899 32203549) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Negative urgency ( 30718321) Pulse pressure ( 30578418 28135244 27841878) Systolic blood pressure ( 30578418 27841878) Total cholesterol levels ( 28334899) White blood cell count ( 32888494)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB	111 interacting genes: ADAMTS4 AMBP ANOS1 APCS ATXN10 ATXN7 C1QA CCN3 CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COL9A1 COMP CRP CTSD CXCL12 DCN DSCR9 DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HOXA1 HRG HSP90AA1 HSPG2 IGFBP3 IGFBP5 ITGA2B ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MTDH MTNR1A MYOC NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 RSPH1 SCGB1A1 SDC2 SGCA SH3GLB1 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TIMD4 TLR4 TMPRSS6 TNC TNFRSF11B TSHR TTN UBQLN1 VEGFA VHL
Entrez ID		7253	2335
HPRD ID		04537	00626
Ensembl ID		ENSG00000165409	ENSG00000115414
Uniprot IDs		P16473	B7ZLE5 P02751 Q9UQS6
PDB IDs		2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48 6HNF 6MFA 6MSV 6NAJ 6XAX 6XAY 7NWL 8PEQ
Enriched GO Terms of Interacting Partners?		G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure	Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibronectin Binding Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Collagen Trimer Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Integrin Binding Cell Adhesion Endoplasmic Reticulum Lumen Cell Surface Developmental Process Negative Regulation Of Multicellular Organismal Process Collagen Type IV Trimer Integrin Complex Signal Transduction Negative Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Response To Growth Factor Cell-matrix Adhesion Regulation Of Cell Adhesion Extracellular Matrix Binding Anatomical Structure Morphogenesis Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Vasculature Development Cell-cell Adhesion Positive Regulation Of Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Positive Regulation Of Locomotion Regulation Of Apoptotic Process Collagen-activated Signaling Pathway Regulation Of Angiogenesis Regulation Of Cell Motility Collagen Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Regulation Of Locomotion Integrin-mediated Signaling Pathway
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