TSHR and SCRIB

Number of citations of the paper that reports this interaction (PMID 15775968)
17

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TSHR	SCRIB
Gene Name		thyroid stimulating hormone receptor	scribbled planar cell polarity protein
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Nucleoplasm Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Basolateral Plasma Membrane Lamellipodium Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Thyroid-stimulating Hormone Receptor Activity Protein Binding	Protein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell-cell Signaling Positive Regulation Of Cell Proliferation Thyroid-stimulating Hormone Signaling Pathway	Neural Tube Closure Positive Regulation Of Receptor Recycling Asymmetric Protein Localization Cell Proliferation Viral Process Synaptic Vesicle Targeting Single Organismal Cell-cell Adhesion Cell Migration Cochlear Nucleus Development Activation Of Rac GTPase Activity Establishment Of Apical/basal Cell Polarity Wound Healing Positive Regulation Of Apoptotic Process Astrocyte Cell Migration Negative Regulation Of Mitotic Cell Cycle Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Asymmetric localization of PCP proteins Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs		Thyrotropin Alfa
Diseases
GWAS		Graves' disease ( 21841780) Hair morphology ( 19896111) Optic disc size (rim) ( 20395239) Visceral fat ( 22589738)
Protein-Protein Interactions		24 interactors: ADRB2 CALR CANX FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HSPA5 JAK1 JAK2 LHCGR PIK3R1 RABAC1 SCRIB STAT3 TSHB UBC	11 interactors: APC ARHGEF7 EXOSC10 LPP MAPK3 PRKCA STX4 TJP2 TRIP6 TSHR UBE3A
Entrez ID		7253	23513
HPRD ID		04537	06984
Ensembl ID		ENSG00000165409	ENSG00000180900
Uniprot IDs		F5GYU5 P16473	A0PJK8 Q14160
PDB IDs		1XUM 2XWT 3G04	1UJU 1WHA 1X5Q 2W4F
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Platelet Activation Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Signaling Cell Communication Response To Stress Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell Activation Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Response To Stimulus Regulation Of Adenylate Cyclase Activity Developmental Process Regulation Of Cyclase Activity Cellular Response To Stimulus Regulation Of CAMP Biosynthetic Process Dopamine Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Localization Anatomical Structure Development Establishment Of Localization In Cell Regulation Of Signaling Regulation Of Cell Migration Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Motility Growth Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Growth Hormone Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Differentiation Multicellular Organismal Development Activation Of Adenylate Cyclase Activity Response To Cytokine Regulation Of Cellular Process Cellular Response To Organic Substance	Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell Junction Assembly Cell-cell Junction Organization Regulation Of Cell Migration Regulation Of Cell Motility Cell Activation Regulation Of Cellular Component Movement Positive Regulation Of Cell Adhesion Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Regulation Of Cellular Localization Cell Death Regulation Of Signal Transduction Death Signaling Platelet Activation Cell Communication Focal Adhesion Assembly Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Adherens Junction Assembly Cell-substrate Junction Assembly Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Sperm Entry Negative Regulation Of Apolipoprotein Binding Positive Regulation Of Dense Core Granule Biogenesis Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Execution Phase Of Apoptosis Neuron Development Response To Interleukin-1 Adherens Junction Organization Cell Development Blood Coagulation Hemostasis Intracellular Signal Transduction Positive Regulation Of Eosinophil Degranulation
Tagcloud ?		adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty	asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport
Tagcloud (Difference) ?		adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty	asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport
Tagcloud (Intersection) ?