TSHR and GNA11

Number of citations of the paper that reports this interaction (PubMedID 8552586)
37

Data Source:
HPRD (in vivo)

		TSHR	GNA11
Description		thyroid stimulating hormone receptor	G protein subunit alpha 11
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Skeletal System Development Action Potential Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Regulation Of Blood Pressure Entrainment Of Circadian Clock Positive Regulation Of Insulin Secretion Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH Endothelin Receptor Signaling Pathway Cranial Skeletal System Development Ligand-gated Ion Channel Signaling Pathway
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Thyrotropin alfa
Diseases		Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	Asthma ( 31959851)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB	17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A NHERF1 PTGIR RGS14 RGS3 TBXA2R TRPC3 TSHR
Entrez ID		7253	2767
HPRD ID		04537	00759
Ensembl ID		ENSG00000165409	ENSG00000088256
Uniprot IDs		P16473	P29992
PDB IDs		2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7	6OIJ 7RKF 7TRY 7XXH
Enriched GO Terms of Interacting Partners?		G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Smooth Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Vascular Process In Circulatory System Circulatory System Process G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Signal Transduction Vasoconstriction Plasma Membrane Muscle Contraction Regulation Of Blood Circulation Muscle System Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Inorganic Ion Homeostasis Membrane System Process Regulation Of Vasoconstriction Vascular Associated Smooth Muscle Contraction Regulation Of Cell Communication Regulation Of Signaling Endothelin Receptor Activity Calcium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of MAPK Cascade Calcium Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Calcium Ion Transport Regulation Of Muscle System Process Regulation Of Intracellular Signal Transduction Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Renal Albumin Absorption G Protein-coupled Serotonin Receptor Complex Regulation Of ERK1 And ERK2 Cascade Ameboidal-type Cell Migration Positive Regulation Of Multicellular Organismal Process Type 1 Angiotensin Receptor Binding Chemical Homeostasis Renal Absorption
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?