TSHR and FLNB

Number of citations of the paper that reports this interaction (PubMedID 8327473)
24

Data Source:
BioGRID (unspecified method)
HPRD (in vitro, in vivo)

		TSHR	FLNB
Description		thyroid stimulating hormone receptor	filamin B
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Neuronal Cell Body Phagocytic Vesicle Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Keratinocyte Development Epithelial Cell Morphogenesis Signal Transduction Muscle Organ Development Skeletal Muscle Tissue Development Actin Cytoskeleton Organization Cell Differentiation Cellular Response To Type II Interferon
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events	ISG15 antiviral mechanism
Drugs		Thyrotropin alfa
Diseases		Congenital nongoitrous hypothyroidism (CHNG)	FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome Spondylocarpotarsal synostosis syndrome
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	A body shape index ( 34021172) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Glaucoma (low intraocular pressure) ( 33627673) Gut microbiota (bacterial taxa) ( 27723756) Height ( 33713608 31217584) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 31798171 28073927 25631615) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB	26 interacting genes: ASB2 ATF7IP DSCAM ERBB2 FBLIM1 FLNA FXR1 GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 RNF216 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR XIAP
Entrez ID		7253	2317
HPRD ID		04537	04543
Ensembl ID		ENSG00000165409	ENSG00000136068
Uniprot IDs		P16473	O75369
PDB IDs		2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7	2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP
Enriched GO Terms of Interacting Partners?		G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure	Cell-cell Adhesion Cell Adhesion Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Protein Activation Cascade Synaptic Membrane Receptor Complex Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Formation Of Radial Glial Scaffolds Positive Regulation Of L-glutamate Import Across Plasma Membrane Signal Transduction Ruffle Membrane Glycoprotein Ib-IX-V Complex C-X3-C Chemokine Binding Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Anchoring Junction Negative Regulation Of Programmed Cell Death Negative Regulation Of Multicellular Organismal Process Focal Adhesion Cell Migration Aspartic Endopeptidase Activity, Intramembrane Cleaving Cell Activation Gamma-secretase Complex Platelet Aggregation Blood Coagulation, Intrinsic Pathway Regulation Of L-glutamate Import Across Plasma Membrane Notch Receptor Processing Coreceptor Activity Protein Maturation Amyloid-beta Formation Cell Motility Homotypic Cell-cell Adhesion Regulation Of Tumor Necrosis Factor Production Glutamatergic Synapse Ubiquitin Protein Ligase Activity Positive Regulation Of Platelet Activation Cell Morphogenesis Actin Cytoskeleton Organization Wound Healing Positive Regulation Of Locomotion Neuromuscular Junction Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Mesodermal Cell Differentiation Cell Development Virus Receptor Activity
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