TSHR and JPH3

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		TSHR	JPH3
Name		thyroid stimulating hormone receptor	junctophilin 3
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Junctional Membrane Complex
	Molecular Function	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Learning Memory Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Exploration Behavior Locomotion Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Calcium Ion Transport Into Cytosol
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events	None
Drugs		Thyrotropin alfa	None
Diseases		Congenital nongoitrous hypothyroidism (CHNG)	Core neuroacanthocytosis syndromes, including: Chorea-acanthocytosis (ChAc); McLeod syndrome (MLS); Huntington's disease-like 2 (HDL2); Pantothenate kinase associated neurodegeneration (PKAN)
GWAS		Graves' disease ( 21841780 22922229 ) Hair morphology ( 19896111 ) Male sexual orientation ( 29217827 ) Maximal oxygen uptake response ( 25729143 ) Obstetric antiphospholipid syndrome ( 28424481 ) Optic nerve measurement (rim area) ( 20395239 ) Smooth-surface caries ( 24556642 ) Thyroid stimulating hormone levels ( 30367059 32769997 ) Tourette syndrome ( 30818990 ) Uric acid levels ( 21294900 ) Urinary albumin excretion ( 32277301 ) Visceral fat ( 22589738 )	Dementia and core Alzheimer's disease neuropathologic changes ( 25188341 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 28552196 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Late-onset Alzheimer's disease ( 27770636 ) Migraine ( 27182965 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317 ) Refractive error ( 32231278 ) Small vessel stroke ( 27997041 ) Systemic juvenile idiopathic arthritis ( 27927641 )
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB	11 interacting genes: BGN CACNA1D CCR2 KCNN4 KRTAP10-8 PPP1CA RSPH1 RYR2 SMAD3 SMO TSHR
Entrez ID		7253	57338
HPRD ID		04537	05589
Ensembl ID		ENSG00000165409	ENSG00000154118
Uniprot IDs		P16473	B4DIC1 F8W9A3 Q8WXH2 Q96HD8
PDB IDs		2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7	Not available
GO Terms Enriched among Interactors		G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure	Epithelial Tube Morphogenesis Tube Morphogenesis Morphogenesis Of An Epithelium Embryonic Heart Tube Morphogenesis Protein Kinase A Catalytic Subunit Binding Tissue Morphogenesis Blood Vessel Remodeling Cytokine Binding Cell Communication Regulation Of Transport Regulation Of Membrane Potential Regulation Of Biological Quality Regulation Of Calcium Ion Transport Calcium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Signaling Cardiac Muscle Cell Action Potential Regulation Of Monoatomic Cation Transmembrane Transport Cellular Homeostasis Intermediate Conductance Calcium-activated Potassium Channel Activity Positive Regulation Of Protein Transport Protein Stabilization Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination Homeostasis Of Number Of Cells Within A Tissue Cellular Response To Thyrotropin-releasing Hormone Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Regulation Of Monoatomic Ion Transmembrane Transport Homeostatic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Heart Looping Regulation Of Potassium Ion Transmembrane Transport Tissue Remodeling Calcium Ion Transmembrane Import Into Cytosol G Protein-coupled Receptor Signaling Pathway Calcium Channel Activity Positive Regulation Of Transport Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Regulation Of Heart Rate Plasma Membrane