STAM and PJA1

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		STAM	PJA1
Gene Name		signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	praja ring finger 1, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Early Endosome Membrane	Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Intracellular Protein Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly	Protein Ubiquitination Protein Catabolic Process
Pathways		Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: ARRB1 CLTC HGS JAK1 JAK2 JAK3 PJA1 PPP1CA PPP1CC RFFL STAMBP TIMM8A TRIM54 TRIM55 TRIM63 UBC USP15 USP28 USP8	36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440
Entrez ID		8027	64219
HPRD ID		03542	02335
Ensembl ID		ENSG00000136738	ENSG00000181191
Uniprot IDs		Q92783	Q8NG27
PDB IDs		2L0A 3F1I 3LDZ	2L0B
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Metabolic Process Regulation Of Proteolysis Signaling Cell Communication Negative Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Modification By Small Protein Removal Cellular Macromolecule Catabolic Process Peptidyl-tyrosine Autophosphorylation Regulation Of Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus STAT Protein Import Into Nucleus Intracellular Transport JAK-STAT Cascade Proteolysis Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Glycogen Metabolic Process Regulation Of Protein Metabolic Process Tyrosine Phosphorylation Of STAT Protein Response To Interleukin-2 Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Polysaccharide Metabolic Process Cellular Response To Organic Substance Cell Cycle Intracellular Protein Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Transport	Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		adaptor cloned coil coiled colony conserved counteracts counterpart deleted exogenous granulocyte hepatocyte hrs inducible introduction kda lost macrophage molecularly molecule mutual phosphotyrosine rapidly stimulating stimulation suppressive transducing transduction tyrosine
Tagcloud (Difference) ?		adaptor cloned coil coiled colony conserved counteracts counterpart deleted exogenous granulocyte hepatocyte hrs inducible introduction kda lost macrophage molecularly molecule mutual phosphotyrosine rapidly stimulating stimulation suppressive transducing transduction tyrosine
Tagcloud (Intersection) ?