STAM

Description		signal transducing adaptor molecule
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane ESCRT-0 Complex
	Molecular Function	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly
Pathways		EGFR downregulation Metalloprotease DUBs Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: MAD1L1
Interacting Genes		21 interacting genes: HGS JAK1 JAK2 JAK3 MAP3K1 PJA1 PMEPA1 PPP1CA PPP1CC RFFL RIPK4 SNCA STAMBP TIMM8A TRIM54 TRIM55 TRIM63 USP15 USP28 USP8 WWP2
Entrez ID		8027
HPRD ID		03542
Ensembl ID		ENSG00000136738
Uniprot IDs		B4DZT2 Q92783
PDB IDs		2L0A 3F1I 3LDZ
Enriched GO Terms of Interacting Partners?		Protein Modification Process Protein Metabolic Process Post-translational Protein Modification Growth Hormone Receptor Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Endosome Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Deubiquitinase Activity Ubiquitin Protein Ligase Activity Protein Deubiquitination Cytoplasm Protein Modification By Small Protein Removal Regulation Of Signal Transduction Metal Ion Binding Macromolecule Metabolic Process Transferase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transduction Interleukin-4-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Signal Transduction PTW/PP1 Phosphatase Complex Interleukin-9-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Extrinsic Component Of Plasma Membrane Interleukin-15-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cytosol Interleukin-2-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Type II Interferon-mediated Signaling Pathway Protein Domain Specific Binding Interleukin-6-mediated Signaling Pathway Postsynapse Cysteine-type Deubiquitinase Activity K63-linked Deubiquitinase Activity Protein Phosphatase Binding K48-linked Deubiquitinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Cytoplasmic Side Of Plasma Membrane Protein Kinase Activity Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding
Tagcloud ?