STAM and USP15

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		STAM	USP15
Gene Name		signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	ubiquitin specific peptidase 15
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Gene Ontology Annotations	Cellular Component	Cytosol Early Endosome Membrane	Nucleus Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitinated Histone Binding
	Biological Process	Intracellular Protein Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly	Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Pathway-restricted SMAD Protein Phosphorylation Regulation Of Proteasomal Protein Catabolic Process
Pathways		Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Pulmonary function decline ( 22424883)
Protein-Protein Interactions		19 interactors: ARRB1 CLTC HGS JAK1 JAK2 JAK3 PJA1 PPP1CA PPP1CC RFFL STAMBP TIMM8A TRIM54 TRIM55 TRIM63 UBC USP15 USP28 USP8	45 interactors: BAP1 BMPR1A BRAP CARD9 CCDC57 FHL1 HIST2H2BE JOSD1 MAD1L1 OTUB1 PHF7 PLA2G2A RBCK1 RNF126 RNF144B SART3 SENP3 SENP8 SMAD3 SPDL1 STAM STK33 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UBE2S UCHL1 UCHL3 USP14 USP20 USP21 USP28 USP33 USP4 USP51 USP7 USP8 YOD1
Entrez ID		8027	9958
HPRD ID		03542	05293
Ensembl ID		ENSG00000136738	ENSG00000135655
Uniprot IDs		Q92783	Q9Y4E8
PDB IDs		2L0A 3F1I 3LDZ	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Metabolic Process Regulation Of Proteolysis Signaling Cell Communication Negative Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Modification By Small Protein Removal Cellular Macromolecule Catabolic Process Peptidyl-tyrosine Autophosphorylation Regulation Of Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus STAT Protein Import Into Nucleus Intracellular Transport JAK-STAT Cascade Proteolysis Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Glycogen Metabolic Process Regulation Of Protein Metabolic Process Tyrosine Phosphorylation Of STAT Protein Response To Interleukin-2 Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Polysaccharide Metabolic Process Cellular Response To Organic Substance Cell Cycle Intracellular Protein Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Transport	Protein Modification By Small Protein Removal Protein Deubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteolysis Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K63-linked Deubiquitination Regulation Of Proteolysis Protein Polyubiquitination Histone Deubiquitination Protein K63-linked Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Viral Release From Host Cell Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Stress Regulation Of Protein Ubiquitination Regulation Of Protein Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Protein Monoubiquitination Protein Autoubiquitination Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Innate Immune Response-activating Signal Transduction
Tagcloud ?		adaptor cloned coil coiled colony conserved counteracts counterpart deleted exogenous granulocyte hepatocyte hrs inducible introduction kda lost macrophage molecularly molecule mutual phosphotyrosine rapidly stimulating stimulation suppressive transducing transduction tyrosine	antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin
Tagcloud (Difference) ?		adaptor cloned coil coiled colony conserved counteracts counterpart deleted exogenous granulocyte hepatocyte hrs inducible introduction kda lost macrophage molecularly molecule mutual phosphotyrosine rapidly stimulating stimulation suppressive transducing transduction tyrosine	antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin
Tagcloud (Intersection) ?