STAM and PMEPA1

Number of citations of the paper that reports this interaction (PubMedID 28218281)
49

Data Source:
BioGRID (pull down)

		STAM	PMEPA1
Description		signal transducing adaptor molecule	prostate transmembrane protein, androgen induced 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane ESCRT-0 Complex	Golgi Membrane Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding	Protein Binding WW Domain Binding R-SMAD Binding Protein Sequestering Activity
	Biological Process	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly	Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of SMAD Protein Signal Transduction
Pathways		EGFR downregulation Metalloprotease DUBs Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)	Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event) ( 33455090) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		21 interacting genes: HGS JAK1 JAK2 JAK3 MAP3K1 PJA1 PMEPA1 PPP1CA PPP1CC RFFL RIPK4 SNCA STAMBP TIMM8A TRIM54 TRIM55 TRIM63 USP15 USP28 USP8 WWP2	11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4
Entrez ID		8027	56937
HPRD ID		03542	09415
Ensembl ID		ENSG00000136738	ENSG00000124225
Uniprot IDs		B4DZT2 Q92783	Q5JY37 Q969W9
PDB IDs		2L0A 3F1I 3LDZ
Enriched GO Terms of Interacting Partners?		Protein Modification Process Protein Metabolic Process Post-translational Protein Modification Growth Hormone Receptor Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Endosome Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Deubiquitinase Activity Ubiquitin Protein Ligase Activity Protein Deubiquitination Cytoplasm Protein Modification By Small Protein Removal Regulation Of Signal Transduction Metal Ion Binding Macromolecule Metabolic Process Transferase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transduction Interleukin-4-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Signal Transduction PTW/PP1 Phosphatase Complex Interleukin-9-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Extrinsic Component Of Plasma Membrane Interleukin-15-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cytosol Interleukin-2-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Type II Interferon-mediated Signaling Pathway Protein Domain Specific Binding Interleukin-6-mediated Signaling Pathway Postsynapse Cysteine-type Deubiquitinase Activity K63-linked Deubiquitinase Activity Protein Phosphatase Binding K48-linked Deubiquitinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Cytoplasmic Side Of Plasma Membrane Protein Kinase Activity Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding	Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Ubiquitin Binding Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway ESCRT-0 Complex Regulation Of Protein Catabolic Process Establishment Of Protein Localization To Vacuole Dynactin Complex Protein Localization To Vacuole Autophagy Establishment Of Protein Localization To Organelle Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of ERAD Pathway Regulation Of Exosomal Secretion Cytosol Regulation Of ERAD Pathway Ubiquitin-like Protein Ligase Binding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Protein Targeting To Lysosome Multivesicular Body Assembly Multivesicular Body Organization Regulation Of Macroautophagy Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Late Endosome To Vacuole Transport Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Protein Targeting To Vacuole Proteolysis Catabolic Process Protein Localization To Lysosome Proteolysis Involved In Protein Catabolic Process Formation Of Structure Involved In A Symbiotic Process Cytoplasm Receptor Internalization Channel Inhibitor Activity Regulation Of Cellular Response To Growth Factor Stimulus TRC Complex Positive Regulation Of Exocytosis Endosome Organization Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Regulation Of Autophagy
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