STAM and TIMM8A

Number of citations of the paper that reports this interaction (PMID 12745081)
4

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		STAM	TIMM8A
Gene Name		signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	translocase of inner mitochondrial membrane 8 homolog A (yeast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Early Endosome Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Metal Ion Binding
	Biological Process	Intracellular Protein Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly	Protein Targeting To Mitochondrion Nervous System Development Cellular Protein Metabolic Process Chaperone-mediated Protein Transport
Pathways		Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: ARRB1 CLTC HGS JAK1 JAK2 JAK3 PJA1 PPP1CA PPP1CC RFFL STAMBP TIMM8A TRIM54 TRIM55 TRIM63 UBC USP15 USP28 USP8	4 interactors: KRT15 STAM STAM2 TIMM13
Entrez ID		8027	1678
HPRD ID		03542	02287
Ensembl ID		ENSG00000136738	ENSG00000126953
Uniprot IDs		Q92783	O60220
PDB IDs		2L0A 3F1I 3LDZ
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Metabolic Process Regulation Of Proteolysis Signaling Cell Communication Negative Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Modification By Small Protein Removal Cellular Macromolecule Catabolic Process Peptidyl-tyrosine Autophosphorylation Regulation Of Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus STAT Protein Import Into Nucleus Intracellular Transport JAK-STAT Cascade Proteolysis Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Glycogen Metabolic Process Regulation Of Protein Metabolic Process Tyrosine Phosphorylation Of STAT Protein Response To Interleukin-2 Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Polysaccharide Metabolic Process Cellular Response To Organic Substance Cell Cycle Intracellular Protein Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Transport See more	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endosomal Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Extracellular Vesicular Exosome Assembly Intracellular Transport Chaperone-mediated Protein Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Localization Establishment Of Localization In Cell Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Exocytosis Protein Targeting To Mitochondrion Negative Regulation Of Signal Transduction Protein Localization To Mitochondrion Negative Regulation Of Signaling See more
Tagcloud ?		adaptor cloned coil coiled colony conserved counteracts counterpart deleted exogenous granulocyte hepatocyte hrs inducible introduction kda lost macrophage molecularly molecule mutual phosphotyrosine rapidly stimulating stimulation suppressive transducing transduction tyrosine	coil coiled coordinates ddp deafness downs dystonia endosomal endosomes hepatocyte immunoreceptor import imported intermembrane itam jensen localizes mohr optic overlaps pull redistribution ribosomes stam1 tranebjaerg transducing translated ultimately zn
Tagcloud (Difference) ?		adaptor cloned colony conserved counteracts counterpart deleted exogenous granulocyte hrs inducible introduction kda lost macrophage molecularly molecule mutual phosphotyrosine rapidly stimulating stimulation suppressive transduction tyrosine	coordinates ddp deafness downs dystonia endosomal endosomes immunoreceptor import imported intermembrane itam jensen localizes mohr optic overlaps pull redistribution ribosomes stam1 tranebjaerg translated ultimately zn
Tagcloud (Intersection) ?		coil coiled hepatocyte transducing