STAM and RFFL

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		STAM	RFFL
Description		signal transducing adaptor molecule	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane ESCRT-0 Complex	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Recycling Endosome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		EGFR downregulation Metalloprotease DUBs Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)	Regulation of TP53 Degradation
Drugs
Diseases
GWAS			Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		21 interacting genes: HGS JAK1 JAK2 JAK3 MAP3K1 PJA1 PMEPA1 PPP1CA PPP1CC RFFL RIPK4 SNCA STAMBP TIMM8A TRIM54 TRIM55 TRIM63 USP15 USP28 USP8 WWP2	24 interacting genes: ATXN3 ATXN3L CFTR EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 PRKN RAB11FIP1 SFN STAM STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		8027	117584
HPRD ID		03542	11489
Ensembl ID		ENSG00000136738	ENSG00000092871
Uniprot IDs		B4DZT2 Q92783	Q8WZ73
PDB IDs		2L0A 3F1I 3LDZ	1Y02
Enriched GO Terms of Interacting Partners?		Protein Modification Process Protein Metabolic Process Post-translational Protein Modification Growth Hormone Receptor Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Endosome Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Deubiquitinase Activity Ubiquitin Protein Ligase Activity Protein Deubiquitination Cytoplasm Protein Modification By Small Protein Removal Regulation Of Signal Transduction Metal Ion Binding Macromolecule Metabolic Process Transferase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transduction Interleukin-4-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Signal Transduction PTW/PP1 Phosphatase Complex Interleukin-9-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Extrinsic Component Of Plasma Membrane Interleukin-15-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cytosol Interleukin-2-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Type II Interferon-mediated Signaling Pathway Protein Domain Specific Binding Interleukin-6-mediated Signaling Pathway Postsynapse Cysteine-type Deubiquitinase Activity K63-linked Deubiquitinase Activity Protein Phosphatase Binding K48-linked Deubiquitinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Cytoplasmic Side Of Plasma Membrane Protein Kinase Activity Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding	Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Proteolysis Cysteine-type Deubiquitinase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Negative Regulation Of TOR Signaling Protein Polyubiquitination Cellular Response To Stress Regulation Of TORC1 Signaling Protein Ubiquitination Ubiquitin Binding Peptidase Activity Positive Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Proteasomal Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process DNA Repair TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Ubiquitin-protein Transferase Activity Catabolic Process DNA Damage Response Regulation Of TOR Signaling Cellular Response To Topologically Incorrect Protein Macromolecule Catabolic Process Regulation Of Protein Polyubiquitination Protein Catabolic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Post-translational Protein Modification Protein Monoubiquitination
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?