MUL1 and UBE2U

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		MUL1	UBE2U
Gene Name		mitochondrial E3 ubiquitin protein ligase 1	ubiquitin-conjugating enzyme E2U (putative)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Membrane Integral Component Of Mitochondrial Outer Membrane	Nuclear Chromatin Cytoplasm HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitochondrial Fission Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: AKT1 APPBP2 DNM1L SUMO1 TAP1 TP53 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2U UBE2W	66 interactors: ANAPC11 BARD1 BFAR CADPS2 CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 VPS11 VPS41 ZSWIM2
Entrez ID		79594	148581
HPRD ID		07799	14599
Ensembl ID		ENSG00000090432	ENSG00000177414
Uniprot IDs		B7Z8S4 Q969V5	Q5VVX9
PDB IDs			1YRV
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Catabolic Process Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Stress Response To Hypoxia Regulation Of DNA-templated Transcription In Response To Stress Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Process Innate Immune Response Protein K63-linked Ubiquitination Response To Stress Cellular Response To DNA Damage Stimulus Positive Regulation Of Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Metabolic Process Regulation Of Viral Release From Host Cell Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Macromolecule Catabolic Process Regulation Of Protein Stability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Regulation Of Gene Expression Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Immune Response Regulation Of Intracellular Transport Cellular Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Defense Response Interferon-gamma-mediated Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Response To Stress Negative Regulation Of Viral Transcription Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Cellular Response To Interferon-gamma Protein Destabilization Regulation Of Signal Transduction
Tagcloud ?		acts aggravates compensates degeneration doi drosophila dx elife finding flies http identifying integrity lethality maintain mammals mitofusin org overexpressed parallel parkin parkinson pd phenotypes pink1 removing shared suppresses suppressors
Tagcloud (Difference) ?		acts aggravates compensates degeneration doi drosophila dx elife finding flies http identifying integrity lethality maintain mammals mitofusin org overexpressed parallel parkin parkinson pd phenotypes pink1 removing shared suppresses suppressors
Tagcloud (Intersection) ?