MUL1 and UBE2E1

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		MUL1	UBE2E1
Gene Name		mitochondrial E3 ubiquitin protein ligase 1	ubiquitin-conjugating enzyme E2E 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Membrane Integral Component Of Mitochondrial Outer Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Mitochondrial Fission Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Histone Monoubiquitination Protein Ubiquitination Cytokine-mediated Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation Histone H2B Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K48-linked Ubiquitination
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation ISG15 antiviral mechanism Interferon Signaling Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Cytokine Signaling in Immune system APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins Antiviral mechanism by IFN-stimulated genes APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: AKT1 APPBP2 DNM1L SUMO1 TAP1 TP53 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2U UBE2W	100 interactors: ARIH2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBWD5 CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCH3 MARCH5 MARCH7 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PARK2 PBX2 POLL POLM RELA RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF25 RNF26 RNF4 RNF40 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM17 TRIM2 TRIM23 TRIM27 TRIM28 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM7 UBA1 UBASH3B UBE2G1 UBE3A UBOX5 UFM1 USP7 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		79594	7324
HPRD ID		07799	04225
Ensembl ID		ENSG00000090432	ENSG00000170142
Uniprot IDs		B7Z8S4 Q969V5	B7Z306 P51965
PDB IDs			1XR9 3BZH 4JJQ
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Catabolic Process Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Stress Response To Hypoxia Regulation Of DNA-templated Transcription In Response To Stress Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Process Innate Immune Response Protein K63-linked Ubiquitination Response To Stress Cellular Response To DNA Damage Stimulus Positive Regulation Of Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Cellular Metabolic Process Protein Monoubiquitination Proteolysis Catabolic Process Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Histone H2A Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Histone H2A Monoubiquitination Response To Misfolded Protein Regulation Of Signal Transduction Histone Modification Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Cellular Process Positive Regulation Of Protein Catabolic Process
Tagcloud ?		acts aggravates compensates degeneration doi drosophila dx elife finding flies http identifying integrity lethality maintain mammals mitofusin org overexpressed parallel parkin parkinson pd phenotypes pink1 removing shared suppresses suppressors	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z ubiquitin ubiquitination
Tagcloud (Difference) ?		acts aggravates compensates degeneration doi drosophila dx elife finding flies http identifying integrity lethality maintain mammals mitofusin org overexpressed parallel parkin parkinson pd phenotypes pink1 removing shared suppresses suppressors	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z ubiquitin ubiquitination
Tagcloud (Intersection) ?