MUL1 and UBE2E3

Number of citations of the paper that reports this interaction (PMID 25224329)
0

Data Source:
BioGRID (two hybrid)

		MUL1	UBE2E3
Gene Name		mitochondrial E3 ubiquitin protein ligase 1	ubiquitin-conjugating enzyme E2E 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Membrane Integral Component Of Mitochondrial Outer Membrane	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity
	Biological Process	Mitochondrial Fission Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Obesity ( 21552555)
Protein-Protein Interactions		20 interactors: AKT1 APPBP2 DNM1L SUMO1 TAP1 TP53 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2U UBE2W	75 interactors: ACVR1 ARID3A ARIH2 ATXN1 BARD1 BRCA1 CADPS2 CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCH5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA RBX1 RCBTB1 RCBTB2 RFWD3 RING1 RMND5B RNF10 RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBC UBOX5 UFM1 WWP2 ZNRF1 ZNRF4
Entrez ID		79594	10477
HPRD ID		07799	05000
Ensembl ID		ENSG00000090432	ENSG00000170035
Uniprot IDs		B7Z8S4 Q969V5	Q969T4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Catabolic Process Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Stress Response To Hypoxia Regulation Of DNA-templated Transcription In Response To Stress Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Process Innate Immune Response Protein K63-linked Ubiquitination Response To Stress Cellular Response To DNA Damage Stimulus Positive Regulation Of Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Metabolic Process Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Histone Ubiquitination Histone H2A Ubiquitination Regulation Of Protein Catabolic Process Cell Cycle Histone Monoubiquitination Response To Stress Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Type I Interferon Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cellular Response To Stress Protein K6-linked Ubiquitination Cell Cycle Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Mitotic Cell Cycle
Tagcloud ?		acts aggravates compensates degeneration doi drosophila dx elife finding flies http identifying integrity lethality maintain mammals mitofusin org overexpressed parallel parkin parkinson pd phenotypes pink1 removing shared suppresses suppressors	conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Difference) ?		acts aggravates compensates degeneration doi drosophila dx elife finding flies http identifying integrity lethality maintain mammals mitofusin org overexpressed parallel parkin parkinson pd phenotypes pink1 removing shared suppresses suppressors	conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Intersection) ?