MUL1

Gene Name		mitochondrial E3 ubiquitin protein ligase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Membrane Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Mitochondrial Fission Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		20 interactors: AKT1 APPBP2 DNM1L SUMO1 TAP1 TP53 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2U UBE2W
Entrez ID		79594
HPRD ID		07799
Ensembl ID		ENSG00000090432
Uniprot IDs		B7Z8S4 Q969V5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Catabolic Process Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Stress Response To Hypoxia Regulation Of DNA-templated Transcription In Response To Stress Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Process Innate Immune Response Protein K63-linked Ubiquitination Response To Stress Cellular Response To DNA Damage Stimulus Positive Regulation Of Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction
Tagcloud ?		acts aggravates compensates degeneration doi drosophila dx elife finding flies http identifying integrity lethality maintain mammals mitofusin org overexpressed parallel parkin parkinson pd phenotypes pink1 removing shared suppresses suppressors