MUL1 and EHD1

Number of citations of the paper that reports this interaction (PubMedID 28596240)
43

Data Source:
BioGRID (pull down)

		MUL1	EHD1
Description		mitochondrial E3 ubiquitin protein ligase 1	EH domain containing 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Membrane Axon Neuronal Cell Body	Cytoplasm Endosome Early Endosome Lipid Droplet Plasma Membrane Cilium Endosome Membrane Membrane Ciliary Pocket Membrane Endocytic Vesicle Platelet Dense Tubular Network Membrane Early Endosome Membrane Cell Projection Perinuclear Region Of Cytoplasm Presynaptic Active Zone Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Mitochondrial Fission Apoptotic Process Positive Regulation Of Metabolic Process Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Positive Regulation Of Developmental Process Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Type 2 Mitophagy	Intracellular Protein Transport Endocytosis Positive Regulation Of Cholesterol Storage Positive Regulation Of Neuron Projection Development Protein Transport Endosomal Transport Cell Projection Organization Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling
Pathways		Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		34 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 KRTAP10-8 MAP3K7 RANGAP1 REEP2 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W UBXN7 ULK1	13 interacting genes: AP2A1 EHBP1 EHD3 HSPB1 IGF1R MICAL1 MUL1 OGT PACSIN2 RAB11FIP2 RBSN RFFL SNAP29
Entrez ID		79594	10938
HPRD ID		07799	09325
Ensembl ID		ENSG00000090432	ENSG00000110047
Uniprot IDs		Q969V5	A0A024R571 B2R5U3 Q9H4M9
PDB IDs		6K2K 6M2C 6M2D	2JQ6 2KFF 2KFG 2KFH 2KSP
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Ubiquitin-protein Transferase Activity Proteolysis Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Nucleotide Binding ATP Binding Protein K11-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Transferase Activity Proteasomal Protein Catabolic Process Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Regulation Of Macroautophagy ISG15-protein Conjugation Cellular Response To Interferon-beta DNA Damage Response Protein K63-linked Ubiquitination Response To Interferon-beta Cellular Response To Stress Cytosol Response To Stress DNA Repair Positive Regulation Of Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of Autophagy Nucleoplasm TORC1 Signaling Negative Regulation Of TORC1 Signaling Apoptotic Mitochondrial Changes DNA Metabolic Process Cellular Response To Nutrient Levels UBC13-MMS2 Complex Protein K6-linked Ubiquitination CGAS/STING Signaling Pathway TOR Signaling Ubiquitin Conjugating Enzyme Complex	Intracellular Protein Localization Vesicle-mediated Transport Protein Transport Endosome Establishment Of Protein Localization Recycling Endosome Membrane Plasma Membrane Ciliary Pocket Membrane Protein Kinase Binding Endocytosis Golgi To Lysosome Transport Cilium Endosome Membrane Import Into Cell Post-Golgi Vesicle-mediated Transport Early Endosome To Golgi Transport Regulation Of Golgi Organization Golgi To Vacuole Transport Cytosolic Transport Membrane Establishment Of Localization In Cell Negative Regulation Of Protein Kinase C Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ciliary Membrane Cytosol Regulation Of Cellular Component Organization Cellular Response To Glucose Stimulus Golgi Vesicle Transport Small GTPase Binding Intracellular Transport P53 Binding Cellular Response To Carbohydrate Stimulus Sulfur Oxidation Hippocampal Mossy Fiber Expansion Cell Projection Early Endosome Negative Regulation Of Intracellular Signal Transduction Protein Kinase C Inhibitor Activity Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Intracellular Glucose Homeostasis Insulin Receptor Activity Protein O-acetylglucosaminyltransferase Activity TRAM-dependent Toll-like Receptor 4 Signaling Pathway F-actin Monooxygenase Activity Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Retrograde Transport, Endosome To Golgi Positive Regulation Of Cold-induced Thermogenesis
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