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TRAF2 and TRIM37
Number of citations of the paper that reports this interaction (PMID
11279055
)
30
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
TRAF2
TRIM37
Gene Name
TNF receptor-associated factor 2
tripartite motif containing 37
Image
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Cytoplasm
Cytosol
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Vesicle Membrane
CD40 Receptor Complex
Membrane Raft
TRAF2-GSTP1 Complex
Cytoplasm
Peroxisome
Cytosol
Aggresome
ESC/E(Z) Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Tumor Necrosis Factor Receptor Binding
CD40 Receptor Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Enzyme Binding
Protein Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Protein Complex Binding
Identical Protein Binding
Sphingolipid Binding
Chromatin Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Biological Process
Positive Regulation Of T Cell Cytokine Production
Protein Complex Assembly
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Activation Of NF-kappaB-inducing Kinase Activity
Protein Catabolic Process
Positive Regulation Of Interleukin-2 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Regulation Of Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Cellular Protein Complex Assembly
Innate Immune Response
Positive Regulation Of T Cell Activation
Regulation Of Immunoglobulin Secretion
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Heterooligomerization
Protein Autoubiquitination
Protein Homotrimerization
Protein K63-linked Ubiquitination
Cellular Response To Nitric Oxide
Positive Regulation Of Protein Homodimerization Activity
Programmed Necrotic Cell Death
Negative Regulation Of Neuron Death
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of NF-kappaB Transcription Factor Activity
Histone H2A Monoubiquitination
Histone H2A-K119 Monoubiquitination
Negative Regulation Of Centriole Replication
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Aggresome Assembly
Pathways
Regulation by c-FLIP
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Dimerization of procaspase-8
Caspase-8 activation by cleavage
Programmed Cell Death
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
Innate Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Testicular germ cell tumor (
23666239
)
Protein-Protein Interactions
247 interactors:
AASDHPPT
ABLIM1
ACTN3
AES
AFF4
AIMP2
ALPL
AMOTL2
ANKRD11
ANKRD36BP1
APEX2
APPL1
AQP1
ARNT2
ARSJ
ASCC1
ATXN1
ATXN7
BAHD1
BANP
BCL10
BEX2
BIRC2
BIRC3
C14orf105
C17orf82
CALCOCO2
CASP8
CASP8AP2
CATSPER1
CAV1
CBX8
CCDC130
CCDC33
CCHCR1
CCNJL
CD27
CD40
CDC20B
CDC42
CDCA3
CDK9
CDKN1B
CEP57L1
CFAP57
CFLAR
CHMP2B
CHUK
CREB5
CRY1
CYB5R2
CYLD
DGCR6
DLGAP5
DTNB
DVL2
EDAR
EDARADD
EFEMP1
EIF4G1
ENKD1
EP300
ERN1
EWSR1
EXOC3-AS1
FADD
FAM107A
FAM120B
FAM192A
FAM90A1
FATE1
FBF1
FBXO28
FDXACB1
FLNA
FNDC3B
FXR2
GABPB1
GCKR
GORASP2
GPKOW
GSG1
GSTP1
HENMT1
HINFP
HIVEP3
IKBKB
IKBKE
IKBKG
IL15RA
IPO11
IQUB
IRF4
ITPK1
JUN
KANSL1
KIAA0408
KIF26B
KIFC3
KLF3
LNX1
LRRK2
LTBR
LZTS2
MALT1
MAP3K14
MAP3K5
MAP3K8
MAP4K2
MAP4K5
MAPK9
MAPRE1
MAST2
MORN3
MPP3
MVP
NATD1
NEBL
NECAP2
NFIL3
NGFR
NGFRAP1
NIF3L1
NMUR2
NR2C2
NRF1
NRIP1
NUDT16L1
NUDT18
PACS2
PCGF5
PDLIM7
PEG3
PGBD1
PIN1
PKN1
PPL
PPP1R18
PRKAB2
PRKRIP1
PSMF1
QARS
RAD23A
RALBP1
RAPGEF4
RASSF5
RBM41
RCOR3
RFX3
RGS14
RIBC2
RIPK1
RIPK2
RIPK3
RIPPLY1
RNF146
RRAS2
SETD5
SH2D4A
SIAH2
SMG9
SMURF2
SNRNP25
SOX30
SOX9
SPATA2
SPG21
SPHK1
SPRY2
SUMO1P1
SYT17
TAB1
TAB2
TAB3
TANK
TAOK3
TBK1
TCEA2
TCEANC
TCEB3B
TDP2
TEKT3
THAP7
THOP1
TICAM1
TIFA
TNF
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF13B
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF25
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF4
TNFSF9
TNIK
TRADD
TRAF1
TRAF3
TRAF3IP2
TRAF5
TRAF6
TRAIP
TRIM31
TRIM37
TRIM42
TROAP
TRPC4AP
TRPT1
TSHZ3
TSSC4
UBE2D1
UBE2N
UBE2V1
UBE2V2
UBQLN4
UBXN11
USF1
USP2
USP4
USP53
USP7
VWA2
YES1
ZBTB16
ZBTB25
ZBTB43
ZBTB49
ZC2HC1C
ZFAND6
ZMAT2
ZNF205
ZNF410
ZNF488
ZNF544
ZNF646
ZNF655
ZNF662
ZSCAN32
59 interactors:
ANKRD11
APEX2
APTX
ARNT2
BYSL
CCDC33
CDC20B
CDK5RAP2
COPB1
CWF19L2
DDX6
DLGAP5
EWSR1
FAM107A
FAM124B
FAM161A
FAM50B
FXR2
KAT5
KIAA0408
KIF9
LTBR
MAGEB18
MCM10
MCRS1
NGFR
NUDT18
PBK
PNKP
PRC1
RASD1
RHPN1
RIBC2
RPL9
SCNM1
SSX2IP
TANK
TCEB3B
TNFRSF1B
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
UBASH3A
UBB
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2U
ZMAT2
ZNF329
ZNF417
ZNF655
Entrez ID
7186
4591
HPRD ID
03538
05463
Ensembl ID
ENSG00000127191
ENSG00000108395
Uniprot IDs
Q12933
A8K0V9
A8K8U4
F8WEE6
O94972
PDB IDs
1CA4
1CA9
1CZY
1CZZ
1D00
1D01
1D0A
1D0J
1F3V
1QSC
3KNV
3M06
3M0A
3M0D
3LRQ
Enriched GO Terms of Interacting Partners
?
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein Metabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cell Death
Programmed Cell Death
Death
Toll-like Receptor 4 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Innate Immune Response-activating Signal Transduction
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor Signaling Pathway
Activation Of Innate Immune Response
Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
Positive Regulation Of Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Innate Immune Response
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Innate Immune Response
Positive Regulation Of Metabolic Process
Signal Transduction
Cellular Response To Stimulus
Cell Communication
Regulation Of Apoptotic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Signaling
Regulation Of Phosphorylation
Immune Response-regulating Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cell Death
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Immune Response
Intracellular Signal Transduction
Protein Polyubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein K48-linked Ubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Cellular Macromolecule Catabolic Process
Regulation Of Innate Immune Response
Protein K11-linked Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein K63-linked Ubiquitination
Cellular Response To Stress
Catabolic Process
Polynucleotide 3' Dephosphorylation
Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Protein Catabolic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of DNA-templated Transcription In Response To Stress
Programmed Cell Death
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To DNA Damage Stimulus
Regulation Of Cell Cycle Phase Transition
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteolysis
Cell Death
Death
Activation Of NF-kappaB-inducing Kinase Activity
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of NIK/NF-kappaB Signaling
Cellular Protein Catabolic Process
DNA Repair
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Proteolysis
Regulation Of Stress-activated MAPK Cascade
NIK/NF-kappaB Signaling
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Metabolic Process
Tagcloud
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf3
traf5
traf6
transduction
Tagcloud (Difference)
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf3
traf5
traf6
transduction
Tagcloud (Intersection)
?