TRAF2 and GSTP1

Number of citations of the paper that reports this interaction (PMID 16636664)
26

Data Source:
BioGRID (imaging technique)
HPRD (in vitro, in vivo)

		TRAF2	GSTP1
Gene Name		TNF receptor-associated factor 2	glutathione S-transferase pi 1
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane CD40 Receptor Complex Membrane Raft TRAF2-GSTP1 Complex	Extracellular Space Intracellular Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Vesicle Extracellular Vesicular Exosome TRAF2-GSTP1 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Protein Complex Binding Identical Protein Binding Sphingolipid Binding	Glutathione Transferase Activity Protein Binding JUN Kinase Binding Kinase Regulator Activity S-nitrosoglutathione Binding Dinitrosyl-iron Complex Binding Nitric Oxide Binding
	Biological Process	Positive Regulation Of T Cell Cytokine Production Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of T Cell Activation Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Protein Autoubiquitination Protein Homotrimerization Protein K63-linked Ubiquitination Cellular Response To Nitric Oxide Positive Regulation Of Protein Homodimerization Activity Programmed Necrotic Cell Death Negative Regulation Of Neuron Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Reactive Oxygen Species Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Protein Kinase Activity Glutathione Metabolic Process Xenobiotic Metabolic Process Central Nervous System Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation Common Myeloid Progenitor Cell Proliferation Nitric Oxide Storage Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of JUN Kinase Activity Small Molecule Metabolic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Negative Regulation Of Monocyte Chemotactic Protein-1 Production Glutathione Derivative Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Regulation by c-FLIP RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Innate Immune System	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Detoxification of Reactive Oxygen Species Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs			Glutathione Clomipramine (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene S-Hydroxycysteine Cibacron Blue Glutathione Sulfonic Acid S-(P-Nitrobenzyl)Glutathione 2-(N-Morpholino)-Ethanesulfonic Acid Glycerol S-Hexylglutathione Carboxymethylenecysteine S-NONYL-CYSTEINE S-(4-BROMOBENZYL)CYSTEINE
Diseases
GWAS
Protein-Protein Interactions		247 interactors: AASDHPPT ABLIM1 ACTN3 AES AFF4 AIMP2 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARNT2 ARSJ ASCC1 ATXN1 ATXN7 BAHD1 BANP BCL10 BEX2 BIRC2 BIRC3 C14orf105 C17orf82 CALCOCO2 CASP8 CASP8AP2 CATSPER1 CAV1 CBX8 CCDC130 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC42 CDCA3 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHMP2B CHUK CREB5 CRY1 CYB5R2 CYLD DGCR6 DLGAP5 DTNB DVL2 EDAR EDARADD EFEMP1 EIF4G1 ENKD1 EP300 ERN1 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM192A FAM90A1 FATE1 FBF1 FBXO28 FDXACB1 FLNA FNDC3B FXR2 GABPB1 GCKR GORASP2 GPKOW GSG1 GSTP1 HENMT1 HINFP HIVEP3 IKBKB IKBKE IKBKG IL15RA IPO11 IQUB IRF4 ITPK1 JUN KANSL1 KIAA0408 KIF26B KIFC3 KLF3 LNX1 LRRK2 LTBR LZTS2 MALT1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MORN3 MPP3 MVP NATD1 NEBL NECAP2 NFIL3 NGFR NGFRAP1 NIF3L1 NMUR2 NR2C2 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PCGF5 PDLIM7 PEG3 PGBD1 PIN1 PKN1 PPL PPP1R18 PRKAB2 PRKRIP1 PSMF1 QARS RAD23A RALBP1 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIPK1 RIPK2 RIPK3 RIPPLY1 RNF146 RRAS2 SETD5 SH2D4A SIAH2 SMG9 SMURF2 SNRNP25 SOX30 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCEA2 TCEANC TCEB3B TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM31 TRIM37 TRIM42 TROAP TRPC4AP TRPT1 TSHZ3 TSSC4 UBE2D1 UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 VWA2 YES1 ZBTB16 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZMAT2 ZNF205 ZNF410 ZNF488 ZNF544 ZNF646 ZNF655 ZNF662 ZSCAN32	15 interactors: APPBP2 FANCC KRT31 KRTAP10-3 KRTAP10-7 KRTAP10-9 MAPK8 MLH1 NOTCH2NL PNO1 PTN SCAF1 SUMO4 TGM2 TRAF2
Entrez ID		7186	2950
HPRD ID		03538	00614
Ensembl ID		ENSG00000127191	ENSG00000084207
Uniprot IDs		Q12933	P09211
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D	10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5GSS 6GSS 7GSS 8GSS 9GSS
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Programmed Cell Death Death Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Signal Transduction Cellular Response To Stimulus Cell Communication Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Signaling Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Immune Response Intracellular Signal Transduction	Cellular Response To Nitric Oxide Cellular Response To Reactive Oxygen Species Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Programmed Necrotic Cell Death Necrotic Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Toll-like Receptor 4 Signaling Pathway Response To Oxidative Stress Protein Complex Assembly Negative Regulation Of Mitotic Recombination Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Response To Inorganic Substance Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Cellular Response To Inorganic Substance Activation Of Innate Immune Response Regulation Of Protein Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death JUN Phosphorylation Positive Regulation Of Cell Death Positive Regulation Of Deacetylase Activity Salivary Gland Cavitation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Cellular Response To Stress Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Spindle Midzone Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Positive Regulation Of Protein Homodimerization Activity Resolution Of Meiotic Recombination Intermediates Regulation Of Innate Immune Response Germ Cell Development Peptidyl-lysine Modification Regulation Of Immunoglobulin Secretion Protein Homooligomerization
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	abolished acetylcysteine acetyltransferase ap1 boxes chloramphenicol consensus construct detoxication division embryogenesis evolved gggaccctcc h2o2 immediately impairs inducer kappa localizes mad nac proliferating protect redox repression share transfection transferase
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	abolished acetylcysteine acetyltransferase ap1 boxes chloramphenicol consensus construct detoxication division embryogenesis evolved gggaccctcc h2o2 immediately impairs inducer kappa localizes mad nac proliferating protect redox repression share transfection transferase
Tagcloud (Intersection) ?