TRAF2 and LZTS2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRAF2	LZTS2
Gene Name		TNF receptor-associated factor 2	leucine zipper, putative tumor suppressor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane CD40 Receptor Complex Membrane Raft TRAF2-GSTP1 Complex	Cytoplasm Centrosome Microtubule Midbody
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Protein Complex Binding Identical Protein Binding Sphingolipid Binding	Protein Binding
	Biological Process	Positive Regulation Of T Cell Cytokine Production Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of T Cell Activation Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Protein Autoubiquitination Protein Homotrimerization Protein K63-linked Ubiquitination Cellular Response To Nitric Oxide Positive Regulation Of Protein Homodimerization Activity Programmed Necrotic Cell Death Negative Regulation Of Neuron Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cytokinesis Kidney Development Mitotic Nuclear Division Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Microtubule Severing Nuclear Export Spindle Midzone Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus
Pathways		Regulation by c-FLIP RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		247 interactors: AASDHPPT ABLIM1 ACTN3 AES AFF4 AIMP2 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARNT2 ARSJ ASCC1 ATXN1 ATXN7 BAHD1 BANP BCL10 BEX2 BIRC2 BIRC3 C14orf105 C17orf82 CALCOCO2 CASP8 CASP8AP2 CATSPER1 CAV1 CBX8 CCDC130 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC42 CDCA3 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHMP2B CHUK CREB5 CRY1 CYB5R2 CYLD DGCR6 DLGAP5 DTNB DVL2 EDAR EDARADD EFEMP1 EIF4G1 ENKD1 EP300 ERN1 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM192A FAM90A1 FATE1 FBF1 FBXO28 FDXACB1 FLNA FNDC3B FXR2 GABPB1 GCKR GORASP2 GPKOW GSG1 GSTP1 HENMT1 HINFP HIVEP3 IKBKB IKBKE IKBKG IL15RA IPO11 IQUB IRF4 ITPK1 JUN KANSL1 KIAA0408 KIF26B KIFC3 KLF3 LNX1 LRRK2 LTBR LZTS2 MALT1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MORN3 MPP3 MVP NATD1 NEBL NECAP2 NFIL3 NGFR NGFRAP1 NIF3L1 NMUR2 NR2C2 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PCGF5 PDLIM7 PEG3 PGBD1 PIN1 PKN1 PPL PPP1R18 PRKAB2 PRKRIP1 PSMF1 QARS RAD23A RALBP1 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIPK1 RIPK2 RIPK3 RIPPLY1 RNF146 RRAS2 SETD5 SH2D4A SIAH2 SMG9 SMURF2 SNRNP25 SOX30 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCEA2 TCEANC TCEB3B TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM31 TRIM37 TRIM42 TROAP TRPC4AP TRPT1 TSHZ3 TSSC4 UBE2D1 UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 VWA2 YES1 ZBTB16 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZMAT2 ZNF205 ZNF410 ZNF488 ZNF544 ZNF646 ZNF655 ZNF662 ZSCAN32	172 interactors: ABT1 AEN ANKRD11 ANKRD36BP1 AP1M1 ARHGAP32 ARMC7 ARNT2 ATPAF2 BAHD1 BEX2 BMS1P5 BYSL C14orf105 C19orf66 C1orf109 C20orf195 C6orf165 C8orf33 CARD9 CBX8 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CEP57L1 CHCHD3 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DYRK1A DYRK1B DYRK2 EHHADH EIF3D EIF4E2 FAM103A1 FAM107A FAM124B FAM161A FAM74A4 FANCL FBF1 FEM1C FGF12 FKBP6 FRG1 FRMD6 GCC1 GEM GFI1B GMCL1P1 GNL3L GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HSPD1 IQCE KAT5 KAZN KIAA1683 KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 MAB21L3 MAGEB4 MEMO1 MORF4L1 MORF4L2 MORN3 MOS MTA1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 OTUB2 PAK7 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R18 PQBP1 PRKAB2 PSMA1 QARS RAC1 RAD51D RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3RF2 SLC15A3 SLC25A6 SLU7 SMIM3 SNHG11 SNW1 SNX31 SPATA2 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 TBC1D7 TCEA2 TCHP TEAD4 THAP10 THAP7 TNIP3 TRAF2 TRIM29 TRIM42 TSNAX TTC23 TXNL4A USF2 USP2 UTP14C WDYHV1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581
Entrez ID		7186	84445
HPRD ID		03538	14341
Ensembl ID		ENSG00000127191	ENSG00000107816
Uniprot IDs		Q12933	Q9BRK4
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Programmed Cell Death Death Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Signal Transduction Cellular Response To Stimulus Cell Communication Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Signaling Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Immune Response Intracellular Signal Transduction	RNA Metabolic Process Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Viral Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Organelle Organization RNA Processing Ribonucleoprotein Complex Assembly Regulation Of Cellular Protein Metabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus RNA Splicing MRNA Processing Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of T Cell Activation Cellular Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	a549 anticancer chemotherapeutic clones credits effectively exposing gltscr2 lats1 making mdr1 nf1 paclitaxel panel predetermined profiling pten regards screen screened shrna shrnas smad4 st14 suppressors tumorigenesis tumorigenic vhl wt1
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	a549 anticancer chemotherapeutic clones credits effectively exposing gltscr2 lats1 making mdr1 nf1 paclitaxel panel predetermined profiling pten regards screen screened shrna shrnas smad4 st14 suppressors tumorigenesis tumorigenic vhl wt1
Tagcloud (Intersection) ?