TRAF2 and SOX9

Number of citations of the paper that reports this interaction (PubMedID 12136106)
32

Data Source:
HPRD (in vitro)

		TRAF2	SOX9
Description		TNF receptor associated factor 2	SRY-box transcription factor 9
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Tumor Necrosis Factor Receptor Superfamily Complex Nucleoplasm Cytoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane Protein-containing Complex CD40 Receptor Complex Receptor Complex Membrane Raft TRAF2-GSTP1 Complex IRE1-TRAF2-ASK1 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Lipid Binding Transferase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein-macromolecule Adaptor Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity Identical Protein Binding Tumor Necrosis Factor Binding Protein-containing Complex Binding Sphingolipid Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein Kinase A Catalytic Subunit Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Pre-mRNA Intronic Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Immunoglobulin Production Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of T Cell Cytokine Production Apoptotic Process Signal Transduction Positive Regulation Of Gene Expression Programmed Cell Death Protein Ubiquitination Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Response To Endoplasmic Reticulum Stress Non-canonical NF-kappaB Signal Transduction TORC1 Signaling TORC2 Signaling T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Innate Immune Response Regulation Of JNK Cascade MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Cellular Response To Nitric Oxide Programmed Necrotic Cell Death Interleukin-17-mediated Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway TORC1 Complex Assembly TORC2 Complex Disassembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Cartilage Condensation Ossification Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Epithelial To Mesenchymal Transition Tissue Homeostasis Hair Follicle Development Morphogenesis Of An Epithelium Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Chondrocyte Development Glandular Epithelial Cell Differentiation Negative Regulation Of Immune System Process Heart Valve Development Heart Valve Morphogenesis Aortic Valve Morphogenesis Heart Valve Formation Endocardial Cushion Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Chondrocyte Hypertrophy Growth Plate Cartilage Chondrocyte Growth Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Cytoskeleton Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Spermatogenesis Central Nervous System Development Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Mesenchymal Cell Proliferation Gene Expression Regulation Of Gene Expression Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neural Crest Cell Development Neural Crest Cell Fate Specification Male Germ-line Sex Determination Glial Cell Fate Specification Cell Differentiation Regulation Of Cell Adhesion Extracellular Matrix Organization Male Sex Determination Negative Regulation Of Ossification Bone Mineralization Negative Regulation Of Bone Mineralization Prostate Gland Development Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Mammary Gland Development Notochord Development Otic Vesicle Formation Endocrine Pancreas Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Lacrimal Gland Development Protein Localization To Nucleus Somatic Stem Cell Population Maintenance Intrahepatic Bile Duct Development Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Photoreceptor Cell Differentiation Neuron Fate Specification Oligodendrocyte Differentiation Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Cartilage Development Sertoli Cell Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Canonical Wnt Signaling Pathway Limb Bud Formation Retinal Rod Cell Differentiation Endochondral Bone Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Type I Pneumocyte Differentiation Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Bronchus Cartilage Development Trachea Cartilage Development Intestinal Epithelial Cell Differentiation Intestinal Epithelial Structure Maintenance Regulation Of Cell Proliferation Involved In Tissue Homeostasis Positive Regulation Of Cartilage Development Regulation Of Branching Involved In Lung Morphogenesis Morphogenesis Of A Branching Epithelium Lung Smooth Muscle Development Cell Proliferation Involved In Heart Morphogenesis Protein-containing Complex Assembly Negative Regulation Of Biomineral Tissue Development ERK1 And ERK2 Cascade Harderian Gland Development Response To Fatty Acid Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Interleukin-1 Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Otic Vesicle Development Cellular Response To BMP Stimulus Renal Vesicle Induction Stem Cell Proliferation Metanephric Tubule Development Ureter Development Ureter Urothelium Development Ureter Smooth Muscle Cell Differentiation Ureter Morphogenesis Metanephric Nephron Tubule Formation Extracellular Matrix Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Anterior Head Development Mesenchymal Cell Apoptotic Process Cell-cell Adhesion Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of MiRNA Transcription Negative Regulation Of Beta-catenin-TCF Complex Assembly Positive Regulation Of Male Gonad Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Deactivation of the beta-catenin transactivating complex Transcriptional regulation by RUNX2 Transcriptional regulation of testis differentiation Transcriptional and post-translational regulation of MITF-M expression and activity Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases			46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Campomelic dysplasia (CD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Platelet distribution width ( 32888494)	Adolescent idiopathic scoliosis (severe) ( 24023777) Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Cervical cancer ( 31488892) Cervical cancer (MTAG) ( 31488892) Chin dimples ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Coronary artery calcification ( 23870195) Facial morphology ( 31763980) Femoral neck bone mineral density ( 22504420) Fractures (paediatric) ( 32742401) Gynecologic disease (multivariate analysis) ( 31488892) Hip bone size ( 31053729) Hyperthyroidism ( 30367059) Intertrochanteric region size ( 31053729) Kidney stones ( 31729369) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Nose morphology ( 29921221) Nose size ( 27182965) Prostate cancer ( 24753544) Pulmonary function (smoking interaction) ( 23284291) Pulmonary function decline ( 22424883) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781)
Interacting Genes		380 interacting genes: AASDHPPT ABLIM1 ACTN3 AFF4 AGR2 AIMP2 AKR1B15 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARHGEF6 ARNT2 ARSJ ASCC1 ATOSB ATXN1 ATXN7 AXIN1 BAHD1 BANP BAZ2B BCL10 BCL6 BEX2 BEX3 BIRC2 BIRC3 BOD1L2 BYSL C22orf15 CALCOCO2 CAPN15 CASP8 CASP8AP2 CATSPER1 CATSPERT CAV1 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC37 CDC42 CDCA3 CDK18 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHCHD2 CHMP2B CHUK CREB5 CRY1 CRY2 CRYBA2 CTCF CWF19L2 CYB5R2 CYLD DDI1 DDX6 DGCR6 DLGAP5 DMTN DRC4 DTNB DVL2 DVL3 DYRK1A EAF1 EBF2 EDAR EDARADD EFEMP1 EFHC1 EGFR EIF4G1 ELOA2 ENKD1 EP300 EP400 ERN1 ETV6 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM124B FAM161A FAM161B FAM50B FAM90A1 FAM9A FARS2 FATE1 FBF1 FBXO28 FDXACB1 FLNA FLYWCH1 FNDC11 FNDC3B FOXN1 FXR1 FXR2 GABPB1 GCA GCKR GEM GORASP2 GPANK1 GPKOW GRIPAP1 GSE1 GSG1 GSTP1 GSTZ1 HENMT1 HINFP HIVEP3 HOXA1 HOXB5 HSPA12B IKBKB IL15RA IMPDH2 INO80B IP6K3 IPO11 IQUB IRF4 ITPK1 ITPRIPL1 JUN KANK2 KANSL1 KIAA0408 KIAA1217 KIF26B KIFC3 KLF3 LENG1 LINC02875 LNX1 LNX2 LONRF1 LRRK2 LTBR LYSMD1 LZTS2 MACROH2A1 MALT1 MAP3K1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MBLAC1 METTL13 MFAP1 MISP MKRN3 MORN3 MOS MPP3 MSRB2 MVP MYO15B NAB2 NATD1 NCAPH2 NEBL NECAP2 NEDD9 NEK6 NFIL3 NFKBID NGFR NHSL2 NIF3L1 NMUR2 NOXA1 NR2C2 NR4A1 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PALS1 PCGF2 PCGF5 PDLIM7 PDZD4 PEG3 PGBD1 PIAS2 PIBF1 PIN1 PKN1 POLR3C POM121 PPL PPP1R18 PRKAB2 PRKRIP1 PRPF18 PSMB1 PSMD9 PSME3IP1 PSMF1 QARS1 QRICH1 RAD23A RAD54L2 RALBP1 RANBP3 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIN1 RIPK1 RIPK2 RIPK3 RIPPLY1 RIPPLY3 RNF146 RNF4 RRAS2 RSPH14 SAMD11 SAXO4 SCNM1 SETD5 SH2D4A SHC3 SIAH2 SMG9 SMURF2 SNAI1 SNRNP25 SOX13 SOX30 SOX5 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCAF1 TCEA2 TCEANC TCL1A TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TIGD4 TLE5 TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM14 TRIM31 TRIM37 TRIM42 TRIM50 TROAP TRPC4AP TRPT1 TSGA10IP TSHZ2 TSHZ3 TSSC4 TTC23 TXN UBC UBE2D1 UBE2D2 UBE2I UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 UTP14C UTP23 VEZF1 VWA2 WASF1 YES1 YJU2B ZBTB16 ZBTB24 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZKSCAN3 ZMAT2 ZMYM5 ZNF205 ZNF250 ZNF35 ZNF410 ZNF417 ZNF438 ZNF488 ZNF544 ZNF572 ZNF574 ZNF646 ZNF648 ZNF655 ZNF662 ZNF688 ZNF774 ZSCAN23 ZSCAN32 ZSWIM3 ZZZ3	22 interacting genes: ATP6V1H CREB1 CREB3L4 CREBBP ELF3 EP300 HERC1 HNF1B HSPA1A KPNB1 MAF MED12 NFIC NFIX NR5A1 PRKACA RCAN1 RUNX2 SPEN TRAF2 UBE2I USP7
Entrez ID		7186	6662
HPRD ID		03538	06427
Ensembl ID		ENSG00000127191	ENSG00000125398
Uniprot IDs		Q12933	P48436
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D 8T5Q	4EUW
Enriched GO Terms of Interacting Partners?		Protein Binding Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Programmed Cell Death Cell Death Positive Regulation Of Post-translational Protein Modification Tumor Necrosis Factor Receptor Activity Positive Regulation Of Protein Modification Process Apoptotic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Identical Protein Binding Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process MAPK Cascade Positive Regulation Of Protein Metabolic Process CD40 Receptor Complex Regulation Of Necroptotic Process Tumor Necrosis Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity Nucleoplasm RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette TORC1 Signaling Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Tissue Development Nucleus Regulation Of Steroid Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intracellular Signal Transduction TOR Signaling Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Enzyme Binding Regulation Of Steroid Metabolic Process Protein Stabilization
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