TRAF2 and TNFSF4

Number of citations of the paper that reports this interaction (PMID 9418902)
33

Data Source:
HPRD (two hybrid)

		TRAF2	TNFSF4
Gene Name		TNF receptor-associated factor 2	tumor necrosis factor (ligand) superfamily, member 4
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane CD40 Receptor Complex Membrane Raft TRAF2-GSTP1 Complex	Extracellular Space Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Protein Complex Binding Identical Protein Binding Sphingolipid Binding	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor Receptor Superfamily Binding
	Biological Process	Positive Regulation Of T Cell Cytokine Production Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of T Cell Activation Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Protein Autoubiquitination Protein Homotrimerization Protein K63-linked Ubiquitination Cellular Response To Nitric Oxide Positive Regulation Of Protein Homodimerization Activity Programmed Necrotic Cell Death Negative Regulation Of Neuron Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Immune Response Signal Transduction Cholesterol Metabolic Process Positive Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Cellular Response To Nitrogen Dioxide CD4-positive, Alpha-beta T Cell Costimulation T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of Cytokine Secretion Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Chemokine (C-C Motif) Ligand 11 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Memory T Cell Activation Positive Regulation Of T-helper 2 Cell Activation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes
Pathways		Regulation by c-FLIP RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Innate Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) Systemic lupus erythematosus ( 23273568 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		247 interactors: AASDHPPT ABLIM1 ACTN3 AES AFF4 AIMP2 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARNT2 ARSJ ASCC1 ATXN1 ATXN7 BAHD1 BANP BCL10 BEX2 BIRC2 BIRC3 C14orf105 C17orf82 CALCOCO2 CASP8 CASP8AP2 CATSPER1 CAV1 CBX8 CCDC130 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC42 CDCA3 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHMP2B CHUK CREB5 CRY1 CYB5R2 CYLD DGCR6 DLGAP5 DTNB DVL2 EDAR EDARADD EFEMP1 EIF4G1 ENKD1 EP300 ERN1 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM192A FAM90A1 FATE1 FBF1 FBXO28 FDXACB1 FLNA FNDC3B FXR2 GABPB1 GCKR GORASP2 GPKOW GSG1 GSTP1 HENMT1 HINFP HIVEP3 IKBKB IKBKE IKBKG IL15RA IPO11 IQUB IRF4 ITPK1 JUN KANSL1 KIAA0408 KIF26B KIFC3 KLF3 LNX1 LRRK2 LTBR LZTS2 MALT1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MORN3 MPP3 MVP NATD1 NEBL NECAP2 NFIL3 NGFR NGFRAP1 NIF3L1 NMUR2 NR2C2 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PCGF5 PDLIM7 PEG3 PGBD1 PIN1 PKN1 PPL PPP1R18 PRKAB2 PRKRIP1 PSMF1 QARS RAD23A RALBP1 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIPK1 RIPK2 RIPK3 RIPPLY1 RNF146 RRAS2 SETD5 SH2D4A SIAH2 SMG9 SMURF2 SNRNP25 SOX30 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCEA2 TCEANC TCEB3B TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM31 TRIM37 TRIM42 TROAP TRPC4AP TRPT1 TSHZ3 TSSC4 UBE2D1 UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 VWA2 YES1 ZBTB16 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZMAT2 ZNF205 ZNF410 ZNF488 ZNF544 ZNF646 ZNF655 ZNF662 ZSCAN32	2 interactors: TNFRSF4 TRAF2
Entrez ID		7186	7292
HPRD ID		03538	04668
Ensembl ID		ENSG00000127191	ENSG00000117586
Uniprot IDs		Q12933	P23510 Q8IV74
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D	2HEV
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Programmed Cell Death Death Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Signal Transduction Cellular Response To Stimulus Cell Communication Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Signaling Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Immune Response Intracellular Signal Transduction	Regulation Of Immunoglobulin Secretion Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of Cell Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Lymphocyte Activation Regulation Of Protein Secretion Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cytokine Production Cellular Response To Cytokine Stimulus Positive Regulation Of Immunoglobulin Secretion Regulation Of Protein Transport Regulation Of Secretion Positive Regulation Of Protein Homodimerization Activity Regulation Of Establishment Of Protein Localization Cellular Response To Nitric Oxide Response To Cytokine Regulation Of Protein Kinase Activity Response To Nitric Oxide Regulation Of Kinase Activity Regulation Of Protein Localization Positive Regulation Of Immune System Process Positive Regulation Of T Cell Cytokine Production Protein Homotrimerization Regulation Of Protein Homodimerization Activity Cellular Response To Reactive Nitrogen Species Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Phosphorylation Regulation Of T Cell Cytokine Production Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of NIK/NF-kappaB Signaling Protein K63-linked Ubiquitination Protein Trimerization Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cytokine Secretion Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation NIK/NF-kappaB Signaling Positive Regulation Of Immunoglobulin Production Defense Response Regulation Of NIK/NF-kappaB Signaling Protein Autoubiquitination Positive Regulation Of B Cell Proliferation
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	atp6v0d2 ctsk gcgr gpnmb granuloma instillation intratracheal lilrb4 lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts toxicological trem2 upregulated
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	atp6v0d2 ctsk gcgr gpnmb granuloma instillation intratracheal lilrb4 lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts toxicological trem2 upregulated
Tagcloud (Intersection) ?