TRAF2 and EBF2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TRAF2	EBF2
Name		TNF receptor associated factor 2	EBF transcription factor 2
Structure			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Tumor Necrosis Factor Receptor Superfamily Complex Nucleoplasm Cytoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane Protein-containing Complex CD40 Receptor Complex Receptor Complex Membrane Raft TRAF2-GSTP1 Complex IRE1-TRAF2-ASK1 Complex	Chromatin Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Lipid Binding Transferase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein-macromolecule Adaptor Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity Identical Protein Binding Tumor Necrosis Factor Binding Protein-containing Complex Binding Sphingolipid Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Immunoglobulin Production Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of T Cell Cytokine Production Apoptotic Process Signal Transduction Positive Regulation Of Gene Expression Programmed Cell Death Protein Ubiquitination Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Response To Endoplasmic Reticulum Stress Non-canonical NF-kappaB Signal Transduction TORC1 Signaling TORC2 Signaling T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Innate Immune Response Regulation Of JNK Cascade MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Cellular Response To Nitric Oxide Programmed Necrotic Cell Death Interleukin-17-mediated Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway TORC1 Complex Assembly TORC2 Complex Disassembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Cell Fate Determination Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Adipose Tissue Development Positive Regulation Of Cold-induced Thermogenesis
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
GWAS		Platelet distribution width ( 32888494 )	Body size at age 10 ( 32376654 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Dupuytren's disease ( 28886342 ) Hip index ( 34021172 ) Inguinal hernia ( 26686553 ) Major depressive disorder ( 27479909 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Multiple system atrophy ( 27629089 ) Prostate cancer ( 23535732 ) Systolic blood pressure ( 27841878 28739976 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		380 interacting genes: AASDHPPT ABLIM1 ACTN3 AFF4 AGR2 AIMP2 AKR1B15 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARHGEF6 ARNT2 ARSJ ASCC1 ATOSB ATXN1 ATXN7 AXIN1 BAHD1 BANP BAZ2B BCL10 BCL6 BEX2 BEX3 BIRC2 BIRC3 BOD1L2 BYSL C22orf15 CALCOCO2 CAPN15 CASP8 CASP8AP2 CATSPER1 CATSPERT CAV1 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC37 CDC42 CDCA3 CDK18 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHCHD2 CHMP2B CHUK CREB5 CRY1 CRY2 CRYBA2 CTCF CWF19L2 CYB5R2 CYLD DDI1 DDX6 DGCR6 DLGAP5 DMTN DRC4 DTNB DVL2 DVL3 DYRK1A EAF1 EBF2 EDAR EDARADD EFEMP1 EFHC1 EGFR EIF4G1 ELOA2 ENKD1 EP300 EP400 ERN1 ETV6 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM124B FAM161A FAM161B FAM50B FAM90A1 FAM9A FARS2 FATE1 FBF1 FBXO28 FDXACB1 FLNA FLYWCH1 FNDC11 FNDC3B FOXN1 FXR1 FXR2 GABPB1 GCA GCKR GEM GORASP2 GPANK1 GPKOW GRIPAP1 GSE1 GSG1 GSTP1 GSTZ1 HENMT1 HINFP HIVEP3 HOXA1 HOXB5 HSPA12B IKBKB IL15RA IMPDH2 INO80B IP6K3 IPO11 IQUB IRF4 ITPK1 ITPRIPL1 JUN KANK2 KANSL1 KIAA0408 KIAA1217 KIF26B KIFC3 KLF3 LENG1 LINC02875 LNX1 LNX2 LONRF1 LRRK2 LTBR LYSMD1 LZTS2 MACROH2A1 MALT1 MAP3K1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MBLAC1 METTL13 MFAP1 MISP MKRN3 MORN3 MOS MPP3 MSRB2 MVP MYO15B NAB2 NATD1 NCAPH2 NEBL NECAP2 NEDD9 NEK6 NFIL3 NFKBID NGFR NHSL2 NIF3L1 NMUR2 NOXA1 NR2C2 NR4A1 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PALS1 PCGF2 PCGF5 PDLIM7 PDZD4 PEG3 PGBD1 PIAS2 PIBF1 PIN1 PKN1 POLR3C POM121 PPL PPP1R18 PRKAB2 PRKRIP1 PRPF18 PSMB1 PSMD9 PSME3IP1 PSMF1 QARS1 QRICH1 RAD23A RAD54L2 RALBP1 RANBP3 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIN1 RIPK1 RIPK2 RIPK3 RIPPLY1 RIPPLY3 RNF146 RNF4 RRAS2 RSPH14 SAMD11 SAXO4 SCNM1 SETD5 SH2D4A SHC3 SIAH2 SMG9 SMURF2 SNAI1 SNRNP25 SOX13 SOX30 SOX5 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCAF1 TCEA2 TCEANC TCL1A TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TIGD4 TLE5 TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM14 TRIM31 TRIM37 TRIM42 TRIM50 TROAP TRPC4AP TRPT1 TSGA10IP TSHZ2 TSHZ3 TSSC4 TTC23 TXN UBC UBE2D1 UBE2D2 UBE2I UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 UTP14C UTP23 VEZF1 VWA2 WASF1 YES1 YJU2B ZBTB16 ZBTB24 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZKSCAN3 ZMAT2 ZMYM5 ZNF205 ZNF250 ZNF35 ZNF410 ZNF417 ZNF438 ZNF488 ZNF544 ZNF572 ZNF574 ZNF646 ZNF648 ZNF655 ZNF662 ZNF688 ZNF774 ZSCAN23 ZSCAN32 ZSWIM3 ZZZ3	3 interacting genes: EBF3 TRAF1 TRAF2
Entrez ID		7186	64641
HPRD ID		03538	16848
Ensembl ID		ENSG00000127191	ENSG00000221818
Uniprot IDs		Q12933	B2RNT0 B7Z934 Q9HAK2
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D 8T5Q	Not available
GO Terms Enriched among Interactors		Protein Binding Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Programmed Cell Death Cell Death Positive Regulation Of Post-translational Protein Modification Tumor Necrosis Factor Receptor Activity Positive Regulation Of Protein Modification Process Apoptotic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Identical Protein Binding Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process MAPK Cascade Positive Regulation Of Protein Metabolic Process CD40 Receptor Complex Regulation Of Necroptotic Process Tumor Necrosis Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process	Thioesterase Binding Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity TORC2 Complex Disassembly Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Ubiquitin Protein Ligase Binding CD27 Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Zinc Ion Binding CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Cellular Response To Reactive Nitrogen Species Response To Nitric Oxide Programmed Necrotic Cell Death Positive Regulation Of T Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of MAP Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-2 Production Vesicle Membrane Signal Transduction Involved In Regulation Of Gene Expression Regulation Of T Cell Cytokine Production Regulation Of RNA Metabolic Process Apoptotic Process Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process