TRAF2 and TNFAIP3

Number of citations of the paper that reports this interaction (PMID 8692885)
81

Data Source:
HPRD (in vivo, two hybrid)

		TRAF2	TNFAIP3
Gene Name		TNF receptor-associated factor 2	tumor necrosis factor, alpha-induced protein 3
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane CD40 Receptor Complex Membrane Raft TRAF2-GSTP1 Complex	Nucleus Cytoplasm Lysosome Centrosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Protein Complex Binding Identical Protein Binding Sphingolipid Binding	Protease Binding DNA Binding Ubiquitin-protein Transferase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ligase Activity Kinase Binding Ubiquitin Binding Protein Self-association
	Biological Process	Positive Regulation Of T Cell Cytokine Production Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of T Cell Activation Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Protein Autoubiquitination Protein Homotrimerization Protein K63-linked Ubiquitination Cellular Response To Nitric Oxide Positive Regulation Of Protein Homodimerization Activity Programmed Necrotic Cell Death Negative Regulation Of Neuron Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Proteolysis Apoptotic Process Inflammatory Response Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K11-linked Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Protein Oligomerization Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Regulation by c-FLIP RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Innate Immune System	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS			Cardiac Troponin-T levels ( 23247143) Celiac disease ( 20190752) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190 19169254) Rheumatoid arthritis ( 20453841 20453842 17982456) Systemic lupus erythematosus ( 23273568 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		247 interactors: AASDHPPT ABLIM1 ACTN3 AES AFF4 AIMP2 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARNT2 ARSJ ASCC1 ATXN1 ATXN7 BAHD1 BANP BCL10 BEX2 BIRC2 BIRC3 C14orf105 C17orf82 CALCOCO2 CASP8 CASP8AP2 CATSPER1 CAV1 CBX8 CCDC130 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC42 CDCA3 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHMP2B CHUK CREB5 CRY1 CYB5R2 CYLD DGCR6 DLGAP5 DTNB DVL2 EDAR EDARADD EFEMP1 EIF4G1 ENKD1 EP300 ERN1 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM192A FAM90A1 FATE1 FBF1 FBXO28 FDXACB1 FLNA FNDC3B FXR2 GABPB1 GCKR GORASP2 GPKOW GSG1 GSTP1 HENMT1 HINFP HIVEP3 IKBKB IKBKE IKBKG IL15RA IPO11 IQUB IRF4 ITPK1 JUN KANSL1 KIAA0408 KIF26B KIFC3 KLF3 LNX1 LRRK2 LTBR LZTS2 MALT1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MORN3 MPP3 MVP NATD1 NEBL NECAP2 NFIL3 NGFR NGFRAP1 NIF3L1 NMUR2 NR2C2 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PCGF5 PDLIM7 PEG3 PGBD1 PIN1 PKN1 PPL PPP1R18 PRKAB2 PRKRIP1 PSMF1 QARS RAD23A RALBP1 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIPK1 RIPK2 RIPK3 RIPPLY1 RNF146 RRAS2 SETD5 SH2D4A SIAH2 SMG9 SMURF2 SNRNP25 SOX30 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCEA2 TCEANC TCEB3B TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM31 TRIM37 TRIM42 TROAP TRPC4AP TRPT1 TSHZ3 TSSC4 UBE2D1 UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 VWA2 YES1 ZBTB16 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZMAT2 ZNF205 ZNF410 ZNF488 ZNF544 ZNF646 ZNF655 ZNF662 ZSCAN32	38 interactors: ARRDC3 CCDC50 CHUK GIT2 IKBKB IKBKG LAPTM5 OCLN RBCK1 RIPK1 RLIM RNF11 RNF14 RNF5 TAX1BP1 TICAM1 TNF TNIP1 TNIP2 TNIP3 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5
Entrez ID		7186	7128
HPRD ID		03538	01857
Ensembl ID		ENSG00000127191	ENSG00000118503
Uniprot IDs		Q12933	P21580
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D	2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Programmed Cell Death Death Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Signal Transduction Cellular Response To Stimulus Cell Communication Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Signaling Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Immune Response Intracellular Signal Transduction	Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Signaling Regulation Of Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Defense Response Apoptotic Process I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Cell Death Death Positive Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Immune System Process Regulation Of Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	125a 7e 99b arthritis clusters conversion depletion exacerbated il15 immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting upregulates upregulating upregulation whereby
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	125a 7e 99b arthritis clusters conversion depletion exacerbated il15 immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting upregulates upregulating upregulation whereby
Tagcloud (Intersection) ?