TRAF2 and LRRK2

Number of citations of the paper that reports this interaction (PMID 20949042)
11

Data Source:
BioGRID (enzymatic study)

		TRAF2	LRRK2
Gene Name		TNF receptor-associated factor 2	leucine-rich repeat kinase 2
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane CD40 Receptor Complex Membrane Raft TRAF2-GSTP1 Complex	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Inclusion Body Axon Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Protein Complex Binding Identical Protein Binding Sphingolipid Binding	SNARE Binding Glycoprotein Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Tubulin Binding Kinase Activity Rho GTPase Binding Syntaxin-1 Binding Clathrin Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding Protein Kinase A Binding
	Biological Process	Positive Regulation Of T Cell Cytokine Production Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of T Cell Activation Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Protein Autoubiquitination Protein Homotrimerization Protein K63-linked Ubiquitination Cellular Response To Nitric Oxide Positive Regulation Of Protein Homodimerization Activity Programmed Necrotic Cell Death Negative Regulation Of Neuron Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Endocytosis Autophagy Response To Oxidative Stress Small GTPase Mediated Signal Transduction Neuromuscular Junction Development Determination Of Adult Lifespan Positive Regulation Of Autophagy Regulation Of Protein Kinase A Signaling Negative Regulation Of Protein Processing Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Protein Localization Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Protein Autophosphorylation Intracellular Distribution Of Mitochondria Neuron Projection Morphogenesis Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Neuron Death Cellular Response To Manganese Ion Reactive Oxygen Species Metabolic Process Regulation Of Mitochondrial Fission Regulation Of Neuron Death Negative Regulation Of Neuron Death Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Peroxidase Activity
Pathways		Regulation by c-FLIP RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Innate Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 21102463) Inflammatory bowel disease ( 23128233) Obesity-related traits ( 23251661) Parkinson's disease ( 21292315 19915576 22438815 21738487)
Protein-Protein Interactions		247 interactors: AASDHPPT ABLIM1 ACTN3 AES AFF4 AIMP2 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARNT2 ARSJ ASCC1 ATXN1 ATXN7 BAHD1 BANP BCL10 BEX2 BIRC2 BIRC3 C14orf105 C17orf82 CALCOCO2 CASP8 CASP8AP2 CATSPER1 CAV1 CBX8 CCDC130 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC42 CDCA3 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHMP2B CHUK CREB5 CRY1 CYB5R2 CYLD DGCR6 DLGAP5 DTNB DVL2 EDAR EDARADD EFEMP1 EIF4G1 ENKD1 EP300 ERN1 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM192A FAM90A1 FATE1 FBF1 FBXO28 FDXACB1 FLNA FNDC3B FXR2 GABPB1 GCKR GORASP2 GPKOW GSG1 GSTP1 HENMT1 HINFP HIVEP3 IKBKB IKBKE IKBKG IL15RA IPO11 IQUB IRF4 ITPK1 JUN KANSL1 KIAA0408 KIF26B KIFC3 KLF3 LNX1 LRRK2 LTBR LZTS2 MALT1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MORN3 MPP3 MVP NATD1 NEBL NECAP2 NFIL3 NGFR NGFRAP1 NIF3L1 NMUR2 NR2C2 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PCGF5 PDLIM7 PEG3 PGBD1 PIN1 PKN1 PPL PPP1R18 PRKAB2 PRKRIP1 PSMF1 QARS RAD23A RALBP1 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIPK1 RIPK2 RIPK3 RIPPLY1 RNF146 RRAS2 SETD5 SH2D4A SIAH2 SMG9 SMURF2 SNRNP25 SOX30 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCEA2 TCEANC TCEB3B TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM31 TRIM37 TRIM42 TROAP TRPC4AP TRPT1 TSHZ3 TSSC4 UBE2D1 UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 VWA2 YES1 ZBTB16 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZMAT2 ZNF205 ZNF410 ZNF488 ZNF544 ZNF646 ZNF655 ZNF662 ZSCAN32	33 interactors: ACTB AKT1 ARFGAP1 ARHGEF7 BAG5 DVL1 DVL2 DVL3 EIF4EBP1 HSPD1 L3MBTL3 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MBP PRKCZ PTPN23 RALYL RIPK2 SH3GL1 SH3GL2 SH3GL3 STK24 STK25 STK3 STRBP TAOK3 TRAF2 TUBA1A
Entrez ID		7186	120892
HPRD ID		03538	10613
Ensembl ID		ENSG00000127191	ENSG00000188906
Uniprot IDs		Q12933	Q17RV3 Q5S007
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D	2ZEJ 3D6T
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Programmed Cell Death Death Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Signal Transduction Cellular Response To Stimulus Cell Communication Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Signaling Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Immune Response Intracellular Signal Transduction	Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Anatomical Structure Development Signal Transduction By Phosphorylation Regulation Of Catalytic Activity Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Signaling Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Developmental Process Regulation Of Signaling Activation Of Innate Immune Response
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf5 traf6 transduction	autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr
Tagcloud (Intersection) ?