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TEC and LYN
Number of citations of the paper that reports this interaction (PMID
11071635
)
19
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
TEC
LYN
Gene Name
tec protein tyrosine kinase
LYN proto-oncogene, Src family tyrosine kinase
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoskeleton
Cell-cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Nucleus
Cytoplasm
Mitochondrial Intermembrane Space
Golgi Apparatus
Cytosol
Plasma Membrane
Postsynaptic Density
Mitochondrial Crista
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Integrin Alpha2-beta1 Complex
Mast Cell Granule
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Lipid Binding
Metal Ion Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Signaling Protein Tyrosine Kinase Activity
Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
SH3 Domain Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Glycosphingolipid Binding
Ion Channel Binding
Phosphoprotein Binding
Biological Process
Adaptive Immune Response
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Platelet Activation
Cell Differentiation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Proliferation
Tissue Regeneration
Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
B Cell Homeostasis
Regulation Of Cytokine Production
Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Phosphorylation
Fc Receptor Mediated Stimulatory Signaling Pathway
Tolerance Induction To Self Antigen
Histamine Secretion By Mast Cell
Platelet Degranulation
Negative Regulation Of Myeloid Leukocyte Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Response To Sterol Depletion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Axon Guidance
Central Nervous System Development
Blood Coagulation
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Response To Toxic Substance
Response To Hormone
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Oligodendrocyte Development
Response To Organic Cyclic Compound
Viral Process
Peptidyl-tyrosine Phosphorylation
Signal Transduction By Phosphorylation
Platelet Activation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
T Cell Costimulation
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Extracellular Stimulus
Response To Insulin
Regulation Of Mast Cell Activation
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Heat
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Response To Drug
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Amino Acid
Regulation Of Mast Cell Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Erythrocyte Differentiation
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Response To Axon Injury
Cytokine Secretion
Regulation Of Cytokine Secretion
Regulation Of Inflammatory Response
Negative Regulation Of Immune Response
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Positive Regulation Of B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Cellular Component Movement
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Negative Regulation Of Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Retinoic Acid
Cellular Response To Peptide Hormone Stimulus
Regulation Of Monocyte Chemotaxis
Regulation Of Platelet Aggregation
Dendritic Cell Differentiation
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways
Signaling by SCF-KIT
Signaling by Interleukins
Fc epsilon receptor (FCERI) signaling
Cytokine Signaling in Immune system
FCERI mediated Ca+2 mobilization
Interleukin-3, 5 and GM-CSF signaling
Innate Immune System
Signaling by the B Cell Receptor (BCR)
Platelet Adhesion to exposed collagen
Axon guidance
Costimulation by the CD28 family
FCERI mediated MAPK activation
Signaling by SCF-KIT
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
Regulation of KIT signaling
FCERI mediated NF-kB activation
EPH-ephrin mediated repulsion of cells
Regulation of signaling by CBL
EPH-Ephrin signaling
Fcgamma receptor (FCGR) dependent phagocytosis
FCGR activation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Innate Immune System
CD28 co-stimulation
CTLA4 inhibitory signaling
Cytokine Signaling in Immune system
Role of LAT2/NTAL/LAB on calcium mobilization
Cell surface interactions at the vascular wall
PECAM1 interactions
Signaling by Interleukins
Fc epsilon receptor (FCERI) signaling
GPVI-mediated activation cascade
FCERI mediated Ca+2 mobilization
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Adaptive Immune System
Growth hormone receptor signaling
Drugs
Diseases
GWAS
Crohn's disease (
23128233
)
Height (
18391951
)
Protein-Protein Interactions
30 interactors:
ARHGEF12
BMX
BTK
DOK1
ERBB2
FASLG
GNA12
IKBKG
JAK1
JAK2
KIT
LYN
PIK3R1
PIK3R2
PIK3R3
PIP4K2A
PIP5K1A
PLCG1
PLCG2
PLK4
PRLR
PTPN18
PTPN21
RHOA
SHC1
SOCS1
STAP1
TP53
VAV1
WAS
115 interactors:
ACTB
ADAM15
BANK1
BCAR1
BTK
CASP3
CASP7
CASP9
CBL
CBLC
CD19
CD22
CD36
CD72
CD79A
CD79B
CDK1
CDK2
CDKN1B
CHST15
CREBBP
CRKL
CSF1R
CSF2RA
CSF2RB
CSF3R
CSK
CSNK2B
CTLA4
DAPP1
DLG4
DOK1
DOK2
DOK3
EGFR
EPOR
EVL
FASLG
FCAR
FCER1G
FCGR2A
FCGR2B
FOLR1
GAB2
GAB3
GP6
GRIA3
HCLS1
HNRNPK
IL1B
IL2RB
IL7R
INPP5D
ITPR1
JAK2
KHDRBS1
KIT
LCP2
LIME1
MAP4K1
MAPK3
MATK
MME
MS4A1
MS4A2
MUC1
NDFIP2
NEDD9
NMT1
NPHS1
PAG1
PAK2
PDE4A
PDE4D
PECAM1
PIK3CG
PILRB
PLCG1
PLCG2
PPP1R15A
PPP1R8
PRAM1
PRKCD
PRKCQ
PRKDC
PTK2
PTK2B
PTPN6
PTPRC
RASA1
RGS16
RPL10
RPS6KB1
RPS6KB2
SH2B2
SHC1
SKAP1
SKAP2
SLC4A1
SNCA
SPHK1
SPHK2
SRC
STAT3
SYK
TEC
TNF
TRAT1
TRIM28
TRIP10
TRPV4
TYK2
UBB
UHRF2
UNC119
Entrez ID
7006
4067
HPRD ID
02786
01301
Ensembl ID
ENSG00000135605
ENSG00000254087
Uniprot IDs
P42680
A8K379
P07948
Q6NUK7
PDB IDs
2LUL
1W1F
1WA7
3A4O
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Innate Immune Response
Fc Receptor Signaling Pathway
Immune Response
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Immune Response
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Signal Transduction
Wound Healing
Immune Response-regulating Signaling Pathway
Response To Organic Substance
Signaling
Defense Response
Response To Wounding
Cell Communication
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Immune System Process
Cell Activation
Regulation Of Signaling
Regulation Of Catalytic Activity
Cellular Response To Stimulus
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Growth Factor
Cell Differentiation
Cellular Response To Peptide Hormone Stimulus
Growth Hormone Receptor Signaling Pathway
Cellular Response To Peptide
Cellular Response To Growth Hormone Stimulus
Movement Of Cell Or Subcellular Component
Phagocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Signal Transduction
Signaling
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Cellular Response To Stimulus
Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Regulation Of Immune System Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Stimulus
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response
Enzyme Linked Receptor Protein Signaling Pathway
Innate Immune Response
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune Response
Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Defense Response
Fc Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Response To Stress
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Protein Metabolic Process
Cell Activation
Regulation Of Signaling
Response To Organic Substance
Regulation Of Protein Phosphorylation
Regulation Of Cellular Process
Regulation Of Cellular Protein Metabolic Process
Locomotion
Positive Regulation Of Protein Modification Process
Response To Wounding
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Blood Coagulation
Positive Regulation Of Protein Phosphorylation
Movement Of Cell Or Subcellular Component
Hemostasis
Regulation Of Protein Kinase Activity
T Cell Receptor Signaling Pathway
Platelet Activation
Tagcloud
?
5r
abrogated
amino
betac
binding
blocked
coupled
created
csf
exact
finding
granulocyte
help
involves
macrophage
map
modules
narrowed
nine
overlapping
permeable
physically
proline
proximal
residues
sequential
site
stearation
unstimulated
Tagcloud (Difference)
?
5r
abrogated
amino
betac
binding
blocked
coupled
created
csf
exact
finding
granulocyte
help
involves
macrophage
map
modules
narrowed
nine
overlapping
permeable
physically
proline
proximal
residues
sequential
site
stearation
unstimulated
Tagcloud (Intersection)
?