LYN and MAP4K1

Number of citations of the paper that reports this interaction (PubMedID 11514608)
48

Data Source:
HPRD (in vitro)

		LYN	MAP4K1
Description		LYN proto-oncogene, Src family tyrosine kinase	mitogen-activated protein kinase kinase kinase kinase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Crista Endocytic Vesicle Membrane Mitochondrial Membrane Protein-containing Complex Integrin Alpha2-beta1 Complex Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component	Cytoplasm Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Enzyme Binding Signaling Receptor Activator Activity Ubiquitin Protein Ligase Binding Gamma-tubulin Binding Glycosphingolipid Binding Transmembrane Transporter Binding Protein-containing Complex Binding Ephrin Receptor Binding Phosphoprotein Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding Phosphatidylinositol 3-kinase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Damage Checkpoint Signaling Cell Morphogenesis B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Innate Immune Response-activating Signaling Pathway Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of B Cell Apoptotic Process Protein Phosphorylation Autophagy Response To Stress Inflammatory Response DNA Damage Response Response To Sterol Depletion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Fatty Acid Transport Peptidyl-tyrosine Phosphorylation Hemopoiesis Erythrocyte Differentiation Eosinophil Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Neuron Projection Development T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-5-mediated Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis C-X-C Chemokine Receptor CXCR4 Signaling Pathway B Cell Proliferation Positive Regulation Of Phosphorylation Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Response To Peptide Hormone Innate Immune Response Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Cellular Response To Lipid Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Neuroinflammatory Response Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Dendritic Cell Apoptotic Process	Protein Phosphorylation JNK Cascade Cell Population Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		GPVI-mediated activation cascade Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Dectin-2 family CD209 (DC-SIGN) signaling CD22 mediated BCR regulation Cyclin D associated events in G1 Platelet Adhesion to exposed collagen Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Dasatinib 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Bosutinib Ponatinib Nintedanib Fostamatinib	Fostamatinib
Diseases
GWAS		Granulocyte count ( 27863252) Height ( 18391951) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Platelet count ( 32888494) Refractive error ( 32231278) Serum thyroid-stimulating hormone levels ( 24852370) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010 27863252 32888494)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		124 interacting genes: ACTB ADAM15 AR BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 COASY CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR ERBB3 ERBB4 EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IGHA1 IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MET MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PRRG4 PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SOCS1 SPHK1 SPHK2 STAT3 SYK TEC TNF TRAT1 TRIM28 TRIM55 TRIM63 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119	24 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 PPP2CA SHC1 STRN4 SYK TMEM101
Entrez ID		4067	11184
HPRD ID		01301	03583
Ensembl ID		ENSG00000254087	ENSG00000104814
Uniprot IDs		A8K379 B4DQ79 P07948 Q6NUK7	Q92918
PDB IDs		1W1F 1WA7 3A4O 5XY1 6NMW 8WFF	6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0 7KAC 7L24 7L25 7L26 7M0K 7M0L 7M0M 7R9L 7R9N 7R9P 7R9T 7SIU 8CDW 8CIJ 8EEC 8FH4 8FJZ 8FKO 8PAR 8PAS 8PAU 8XN7 9BI8 9BIK 9BJ1 9CZT 9CZU 9CZW 9CZX 9D00 9H8D 9H8E 9H8F
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Plasma Membrane Antigen Receptor-mediated Signaling Pathway Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Regulation Of Apoptotic Process Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Immune Response Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling B Cell Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Adaptive Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell Activation Immune Response T Cell Receptor Signaling Pathway Protein Kinase Activity Negative Regulation Of Programmed Cell Death Kinase Activity Phosphorylation Protein Phosphorylation Regulation Of Multicellular Organismal Process B Cell Activation Regulation Of Transport Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Cell Activation Regulation Of MAPK Cascade External Side Of Plasma Membrane Leukocyte Activation Regulation Of Leukocyte Proliferation	Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Ephrin Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Signal Transduction Positive Regulation Of Immune Response Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Immune System Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Receptor Tyrosine Kinase Binding Lymphocyte Homeostasis Leukocyte Activation Regulation Of T Cell Activation Leukocyte Homeostasis Lymphocyte Activation Cell Activation Positive Regulation Of Cell Population Proliferation Homeostasis Of Number Of Cells Cytosol Positive Regulation Of Cell Adhesion SH2 Domain Binding Regulation Of Lymphocyte Activation Protein Domain Specific Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway
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