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TEC and PIP4K2A
Number of citations of the paper that reports this interaction (PMID
14614854
)
33
Data Source:
HPRD
(in vivo, in vitro)
TEC
PIP4K2A
Gene Name
tec protein tyrosine kinase
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoskeleton
Cell-cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cellular_component
Nucleus
Cytosol
Plasma Membrane
Molecular Function
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Lipid Binding
Metal Ion Binding
ATP Binding
1-phosphatidylinositol-4-phosphate 5-kinase Activity
1-phosphatidylinositol-5-phosphate 4-kinase Activity
Biological Process
Adaptive Immune Response
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Platelet Activation
Cell Differentiation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Proliferation
Tissue Regeneration
Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Megakaryocyte Development
Small Molecule Metabolic Process
Phosphatidylinositol Phosphorylation
Pathways
Signaling by SCF-KIT
Signaling by Interleukins
Fc epsilon receptor (FCERI) signaling
Cytokine Signaling in Immune system
FCERI mediated Ca+2 mobilization
Interleukin-3, 5 and GM-CSF signaling
Innate Immune System
Synthesis of PIPs at the plasma membrane
Metabolism of lipids and lipoproteins
Phospholipid metabolism
PI Metabolism
Drugs
Diseases
GWAS
Crohn's disease (
23128233
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
30 interactors:
ARHGEF12
BMX
BTK
DOK1
ERBB2
FASLG
GNA12
IKBKG
JAK1
JAK2
KIT
LYN
PIK3R1
PIK3R2
PIK3R3
PIP4K2A
PIP5K1A
PLCG1
PLCG2
PLK4
PRLR
PTPN18
PTPN21
RHOA
SHC1
SOCS1
STAP1
TP53
VAV1
WAS
4 interactors:
BTK
GSTK1
RAC1
TEC
Entrez ID
7006
5305
HPRD ID
02786
11931
Ensembl ID
ENSG00000135605
ENSG00000150867
Uniprot IDs
P42680
P48426
PDB IDs
2LUL
2YBX
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Innate Immune Response
Fc Receptor Signaling Pathway
Immune Response
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Immune Response
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Signal Transduction
Wound Healing
Immune Response-regulating Signaling Pathway
Response To Organic Substance
Signaling
Defense Response
Response To Wounding
Cell Communication
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Immune System Process
Cell Activation
Regulation Of Signaling
Regulation Of Catalytic Activity
Cellular Response To Stimulus
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Growth Factor
Cell Differentiation
Cellular Response To Peptide Hormone Stimulus
Growth Hormone Receptor Signaling Pathway
Cellular Response To Peptide
Cellular Response To Growth Hormone Stimulus
Movement Of Cell Or Subcellular Component
Phagocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Tissue Development
Immune Response-regulating Signaling Pathway
Regulation Of Cell Activation
Positive Regulation Of Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Inner Ear Morphogenesis
Innate Immune Response
Ear Morphogenesis
Regulation Of B Cell Cytokine Production
Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Immune System Process
Mesoderm Development
Embryonic Olfactory Bulb Interneuron Precursor Migration
Negative Regulation Of Interleukin-23 Production
Cellular Response To Molecule Of Fungal Origin
Inner Ear Development
Response To Reactive Oxygen Species
Pallium Development
Cell Differentiation
Protein Autophosphorylation
Engulfment Of Apoptotic Cell
Ear Development
Response To Molecule Of Fungal Origin
Vestibular Reflex
Mast Cell Chemotaxis
Immune Response
Regulation Of Immune System Process
Defense Response
Adaptive Immune Response
Peptidyl-tyrosine Phosphorylation
Telencephalon Development
Regulation Of Apoptotic Process
Positive Regulation Of Cell Activation
Regulation Of Cell Death
Embryonic Organ Morphogenesis
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Apoptotic Signaling Pathway
Olfactory Bulb Interneuron Development
Axon Guidance
Regulation Of Lymphocyte Activation
Regulation Of Hydrogen Peroxide Metabolic Process
Cell Development
Tagcloud
?
accompanied
amplification
bearing
cancers
dramatic
encoding
express
homozygous
importantly
kinases
knocking
lethality
littermates
phosphate
phosphatidylinositol
plastic
preventing
ros
senescence
subset
synthetic
tp53
treating
viable
xenografts
Tagcloud (Difference)
?
accompanied
amplification
bearing
cancers
dramatic
encoding
express
homozygous
importantly
kinases
knocking
lethality
littermates
phosphate
phosphatidylinositol
plastic
preventing
ros
senescence
subset
synthetic
tp53
treating
viable
xenografts
Tagcloud (Intersection)
?