TEC and PTPN21

Number of citations of the paper that reports this interaction (PMID 11013262)
8

Data Source:
HPRD (in vivo)

		TEC	PTPN21
Gene Name		tec protein tyrosine kinase	protein tyrosine phosphatase, non-receptor type 21
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytoplasm Cytoskeleton
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Lipid Binding Metal Ion Binding	Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Proliferation Tissue Regeneration Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Signaling by SCF-KIT Signaling by Interleukins Fc epsilon receptor (FCERI) signaling Cytokine Signaling in Immune system FCERI mediated Ca+2 mobilization Interleukin-3, 5 and GM-CSF signaling Innate Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 23128233)
Protein-Protein Interactions		30 interactors: ARHGEF12 BMX BTK DOK1 ERBB2 FASLG GNA12 IKBKG JAK1 JAK2 KIT LYN PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 RHOA SHC1 SOCS1 STAP1 TP53 VAV1 WAS	5 interactors: AKAP1 BMX KIF1C SRC TEC
Entrez ID		7006	11099
HPRD ID		02786	04468
Ensembl ID		ENSG00000135605	ENSG00000070778
Uniprot IDs		P42680	Q16825
PDB IDs		2LUL
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Signal Transduction Wound Healing Immune Response-regulating Signaling Pathway Response To Organic Substance Signaling Defense Response Response To Wounding Cell Communication Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Organic Substance Regulation Of Immune System Process Cell Activation Regulation Of Signaling Regulation Of Catalytic Activity Cellular Response To Stimulus Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Growth Factor Cell Differentiation Cellular Response To Peptide Hormone Stimulus Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Cellular Response To Growth Hormone Stimulus Movement Of Cell Or Subcellular Component Phagocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation	Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Integrin-mediated Signaling Pathway Response To Hydrogen Peroxide Mesoderm Development Innate Immune Response Cellular Response To Progesterone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification Response To Reactive Oxygen Species Intracellular Receptor Signaling Pathway Vestibular Reflex Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Fc Receptor Signaling Pathway Adaptive Immune Response Regulation Of Podosome Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Immune Response Regulation Of Caveolin-mediated Endocytosis Protein Phosphorylation Defense Response Osteoclast Development Negative Regulation Of Protein Oligomerization Response To Stress Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Semicircular Canal Morphogenesis Regulation Of Integrin Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Axon Guidance Transcytosis Cellular Response To Organic Cyclic Compound Signal Complex Assembly Semicircular Canal Development Stress Fiber Assembly Cellular Response To Lipid Blood Coagulation Response To Oxidative Stress
Tagcloud ?			16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 idcs impc impcs micropapillary pangenomic polarity q22 sawtooth sec63 sptlc3 ubr4 unsupervised
Tagcloud (Difference) ?			16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 idcs impc impcs micropapillary pangenomic polarity q22 sawtooth sec63 sptlc3 ubr4 unsupervised
Tagcloud (Intersection) ?