LYN and GAB2

  • Number of citations of the paper that reports this interaction (PMID 11971018)
  • 14
  • Data Source:
  • HPRD (in vivo)

LYN

GAB2

Gene Name LYN proto-oncogene, Src family tyrosine kinase GRB2-associated binding protein 2
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease (late onset) ( 17553421)
  • Menarche (age at onset) ( 21102462)
Protein-Protein Interactions 115 interactors: ACTB ADAM15 BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SPHK1 SPHK2 SRC STAT3 SYK TEC TNF TRAT1 TRIM28 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119 28 interactors: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TNFRSF11A ZAP70
Entrez ID 4067 9846
HPRD ID 01301 05866
Ensembl ID ENSG00000254087 ENSG00000033327
Uniprot IDs A8K379 P07948 Q6NUK7 Q9UQC2
PDB IDs 1W1F 1WA7 3A4O 2VWF 2W0Z
Enriched GO Terms of Interacting Partners?
Tagcloud ?
5r  abrogated  amino  betac  binding  blocked  coupled  created  csf  exact  finding  granulocyte  help  involves  macrophage  map  modules  narrowed  nine  overlapping  permeable  physically  proline  proximal  residues  sequential  site  stearation  unstimulated 
adaptor  adenocarcinomas  compensate  contribution  deletion  demonstrating  driven  egfr  egfrl858r  erbb2  erbb3  gab1  inducible  initiate  inositol  member  met  mutant  observations  phosphatidyl  pi3k  plasticity  remarkable  retained  tamoxifen  tetracycline  tkis  tumorigenesis 
Tagcloud (Difference) ?
5r  abrogated  amino  betac  binding  blocked  coupled  created  csf  exact  finding  granulocyte  help  involves  macrophage  map  modules  narrowed  nine  overlapping  permeable  physically  proline  proximal  residues  sequential  site  stearation  unstimulated 
adaptor  adenocarcinomas  compensate  contribution  deletion  demonstrating  driven  egfr  egfrl858r  erbb2  erbb3  gab1  inducible  initiate  inositol  member  met  mutant  observations  phosphatidyl  pi3k  plasticity  remarkable  retained  tamoxifen  tetracycline  tkis  tumorigenesis 
Tagcloud (Intersection) ?