TEC and PIP5K1A

Number of citations of the paper that reports this interaction (PubMedID 14614854)
0

Data Source:
HPRD (in vitro, in vivo)

		TEC	PIP5K1A
Description		tec protein tyrosine kinase	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Membrane Nuclear Speck Lamellipodium Ruffle Membrane Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding	Nucleotide Binding 1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Kinase Binding Phosphatidylinositol Kinase Activity 1-phosphatidylinositol-5-kinase Activity
	Biological Process	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Cell Migration Actin Cytoskeleton Organization Keratinocyte Differentiation Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Focal Adhesion Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)	Body mass index ( 26426971)
Interacting Genes		37 interacting genes: ARHGEF12 BMX BTK DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS	16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC
Entrez ID		7006	8394
HPRD ID		02786	04470
Ensembl ID		ENSG00000135605	ENSG00000143398
Uniprot IDs		P42680	A6PW57 Q99755
PDB IDs		2LUL
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process	Regulation Of Vesicle-mediated Transport Regulation Of Transport Regulation Of Biological Quality Vesicle-mediated Transport Intracellular Signal Transduction GTPase Activity Phospholipase D Activity GTP Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Establishment Of Localization In Cell Endocytosis Presynapse Plasma Membrane Nucleotide Binding Intracellular Signaling Cassette Response To External Biotic Stimulus Intracellular Copper Ion Homeostasis Golgi Apparatus Regulation Of Synaptic Vesicle Cycle Small GTPase-mediated Signal Transduction Negative Regulation Of B Cell Proliferation Copper Ion Homeostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Endocytosis Response To Light Stimulus Regulation Of Receptor-mediated Endocytosis Import Into Cell Response To Molecule Of Bacterial Origin Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Cell Communication Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Signaling Rac Protein Signal Transduction Phosphatidic Acid Biosynthetic Process Perinuclear Region Of Cytoplasm Regulation Of Interleukin-6 Production Negative Regulation Of Cell Population Proliferation Phosphatidic Acid Metabolic Process Regulation Of Rac Protein Signal Transduction Negative Regulation Of B Cell Activation Positive Regulation Of Inflammatory Response Glycerophospholipid Biosynthetic Process Regulation Of Tumor Necrosis Factor Production Focal Adhesion Regulation Of Signal Transduction MiRNA-mediated Gene Silencing By MRNA Destabilization Response To Radiation
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