LYN and CSK

Number of citations of the paper that reports this interaction (PMID 8612628)
3

Data Source:
HPRD (in vitro)

		LYN	CSK
Gene Name		LYN proto-oncogene, Src family tyrosine kinase	c-src tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Mitochondrial Crista Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Integrin Alpha2-beta1 Complex Mast Cell Granule Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Enzyme Binding Ubiquitin Protein Ligase Binding Glycosphingolipid Binding Ion Channel Binding Phosphoprotein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Identical Protein Binding Proline-rich Region Binding
	Biological Process	B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation Inflammatory Response Cellular Response To DNA Damage Stimulus Response To Sterol Depletion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Central Nervous System Development Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Response To Organic Cyclic Compound Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Platelet Activation Erythrocyte Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Extracellular Stimulus Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Cytokine Secretion Regulation Of Cytokine Secretion Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Cellular Component Movement Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Cellular Response To Peptide Hormone Stimulus Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Dendritic Cell Apoptotic Process	Regulation Of Cytokine Production Morphogenesis Of An Epithelium Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Cell Differentiation Platelet Activation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus
Pathways		Signaling by the B Cell Receptor (BCR) Platelet Adhesion to exposed collagen Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation Signaling by SCF-KIT EPHB-mediated forward signaling EPHA-mediated growth cone collapse Regulation of KIT signaling FCERI mediated NF-kB activation EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System CD28 co-stimulation CTLA4 inhibitory signaling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Cell surface interactions at the vascular wall PECAM1 interactions Signaling by Interleukins Fc epsilon receptor (FCERI) signaling GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Growth hormone receptor signaling	Costimulation by the CD28 family GAB1 signalosome Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFR TCR signaling Signaling by EGFR in Cancer PD-1 signaling Platelet activation, signaling and aggregation Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs			Staurosporine
Diseases
GWAS		Height ( 18391951)	Blood pressure ( 21909110) Caffeine consumption ( 21490707) Diastolic blood pressure ( 19430479 19430483) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		115 interactors: ACTB ADAM15 BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SPHK1 SPHK2 SRC STAT3 SYK TEC TNF TRAT1 TRIM28 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119	46 interactors: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDH5 CREBBP DAB2 DOK1 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 ZAP70 ZNF212
Entrez ID		4067	1445
HPRD ID		01301	00496
Ensembl ID		ENSG00000254087	ENSG00000103653
Uniprot IDs		A8K379 P07948 Q6NUK7	A8K3B6 B2R6Q4 P41240
PDB IDs		1W1F 1WA7 3A4O	1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
Enriched GO Terms of Interacting Partners?		Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Intracellular Signal Transduction Positive Regulation Of Immune System Process Defense Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Cell Activation Regulation Of Signaling Response To Organic Substance Regulation Of Protein Phosphorylation Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Locomotion Positive Regulation Of Protein Modification Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Blood Coagulation Positive Regulation Of Protein Phosphorylation Movement Of Cell Or Subcellular Component Hemostasis Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Platelet Activation	Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cell Adhesion Protein Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Regulation Of Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Immune System Process Regulation Of Intracellular Signal Transduction Response To Peptide Positive Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Intracellular Signal Transduction Leukocyte Migration Positive Regulation Of Cellular Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Response To Wounding Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Wound Healing Negative Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune Response Innate Immune Response
Tagcloud ?		5r abrogated amino betac binding blocked coupled created csf exact finding granulocyte help involves macrophage map modules narrowed nine overlapping permeable physically proline proximal residues sequential site stearation unstimulated	associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections
Tagcloud (Difference) ?		5r abrogated amino betac binding blocked coupled created csf exact finding granulocyte help involves macrophage map modules narrowed nine overlapping permeable physically proline proximal residues sequential site stearation unstimulated	associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections
Tagcloud (Intersection) ?