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TEC and FASLG
Number of citations of the paper that reports this interaction (PMID
19807924
)
2
Data Source:
BioGRID
(unspecified method)
TEC
FASLG
Gene Name
tec protein tyrosine kinase
Fas ligand (TNF superfamily, member 6)
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoskeleton
Cell-cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Extracellular Region
Extracellular Space
Nucleus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Cytoplasmic Membrane-bounded Vesicle Lumen
Extracellular Vesicular Exosome
Molecular Function
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Lipid Binding
Metal Ion Binding
Receptor Binding
Death Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Biological Process
Adaptive Immune Response
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Platelet Activation
Cell Differentiation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Proliferation
Tissue Regeneration
Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Cell Apoptotic Process
Immune Response
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Angiogenesis
Cellular Chloride Ion Homeostasis
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Retinal Cell Programmed Cell Death
Endosomal Lumen Acidification
T Cell Apoptotic Process
Necroptotic Process
Response To Growth Factor
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Positive Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Signaling by SCF-KIT
Signaling by Interleukins
Fc epsilon receptor (FCERI) signaling
Cytokine Signaling in Immune system
FCERI mediated Ca+2 mobilization
Interleukin-3, 5 and GM-CSF signaling
Innate Immune System
Death Receptor Signalling
FasL/ CD95L signaling
Programmed Cell Death
Extrinsic Pathway
Drugs
Diseases
GWAS
Crohn's disease (
23128233
)
Celiac disease (
20190752
)
Crohn's disease (
21102463
23128233
)
Protein-Protein Interactions
30 interactors:
ARHGEF12
BMX
BTK
DOK1
ERBB2
FASLG
GNA12
IKBKG
JAK1
JAK2
KIT
LYN
PIK3R1
PIK3R2
PIK3R3
PIP4K2A
PIP5K1A
PLCG1
PLCG2
PLK4
PRLR
PTPN18
PTPN21
RHOA
SHC1
SOCS1
STAP1
TP53
VAV1
WAS
74 interactors:
APBB1
ARHGAP9
BAIAP2L1
BTK
CACNB3
CACNB4
CRK
DAXX
DLG2
DMD
DNMBP
DOCK4
EPS8L3
EZR
FADD
FAS
FGR
FN1
FNBP1
FYB
FYN
GRAP
GRAP2
GRB2
HCK
ITK
ITSN2
KALRN
KMT2A
KRT40
LCK
LYN
MACC1
MIA
MMP7
MPP4
MYO15A
NCF1
NCK1
NCK2
NCKIPSD
NOTCH2NL
OSTF1
PACSIN2
PDCD6
PIK3CA
PIK3R1
PIN1
PPIAP11
PRPF40A
PSTPIP1
PTPN13
RGS20
RIMBP3C
SAMSN1
SH3GL3
SH3PXD2A
SH3PXD2B
SH3RF2
SKAP2
SNX33
SNX9
SORBS3
SPTA1
SRC
SRGAP1
SRGAP2
SRGAP3
SUMO1
TEC
TJP3
TNFRSF6B
TRIP6
YES1
Entrez ID
7006
356
HPRD ID
02786
00610
Ensembl ID
ENSG00000135605
ENSG00000117560
Uniprot IDs
P42680
P48023
Q53ZZ1
PDB IDs
2LUL
1BZI
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Innate Immune Response
Fc Receptor Signaling Pathway
Immune Response
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Immune Response
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Signal Transduction
Wound Healing
Immune Response-regulating Signaling Pathway
Response To Organic Substance
Signaling
Defense Response
Response To Wounding
Cell Communication
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Immune System Process
Cell Activation
Regulation Of Signaling
Regulation Of Catalytic Activity
Cellular Response To Stimulus
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Growth Factor
Cell Differentiation
Cellular Response To Peptide Hormone Stimulus
Growth Hormone Receptor Signaling Pathway
Cellular Response To Peptide
Cellular Response To Growth Hormone Stimulus
Movement Of Cell Or Subcellular Component
Phagocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Fc Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Innate Immune Response
Immune System Process
Regulation Of Immune System Process
Regulation Of Cell Activation
Endocytosis
Positive Regulation Of Cell Activation
Immune Response
Regulation Of Cellular Process
T Cell Receptor Signaling Pathway
Axon Guidance
Regulation Of Lymphocyte Activation
Signal Transduction
Locomotion
Positive Regulation Of T Cell Activation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Homotypic Cell-cell Adhesion
Defense Response
Movement Of Cell Or Subcellular Component
Positive Regulation Of Cell-cell Adhesion
Signaling
Regulation Of Signal Transduction
Cell Communication
Chemotaxis
T Cell Costimulation
Axonogenesis
Response To External Stimulus
Regulation Of T Cell Activation
Positive Regulation Of Cell Adhesion
Axon Development
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Metabolic Process
Vesicle-mediated Transport
Cell Morphogenesis Involved In Neuron Differentiation
Phagocytosis
Regulation Of Signaling
Cell Morphogenesis Involved In Differentiation
Cell Migration
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Tagcloud
?
casp3
cl
coincided
corpora
cyclic
disaggregation
estrous
extrinsic
fos
ifng
ifngamma
jun
lutea
luteal
luteolysis
luteolytic
p4
pgf2alpha
postmortem
pregnancy
proportions
tnfa
tnfr1
tnfr2
tnfrsf1a
tnfrsf1b
viable
Tagcloud (Difference)
?
casp3
cl
coincided
corpora
cyclic
disaggregation
estrous
extrinsic
fos
ifng
ifngamma
jun
lutea
luteal
luteolysis
luteolytic
p4
pgf2alpha
postmortem
pregnancy
proportions
tnfa
tnfr1
tnfr2
tnfrsf1a
tnfrsf1b
viable
Tagcloud (Intersection)
?