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TEC and KIT
Number of citations of the paper that reports this interaction (PMID
7526158
)
15
Data Source:
HPRD
(in vitro, in vivo)
TEC
KIT
Gene Name
tec protein tyrosine kinase
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoskeleton
Cell-cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Acrosomal Vesicle
Extracellular Space
Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Integral Component Of Membrane
Mast Cell Granule
Molecular Function
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Lipid Binding
Metal Ion Binding
Protease Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Receptor Signaling Protein Tyrosine Kinase Activity
Stem Cell Factor Receptor Activity
Protein Binding
ATP Binding
Cytokine Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Adaptive Immune Response
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Platelet Activation
Cell Differentiation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Proliferation
Tissue Regeneration
Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Activation Of MAPK Activity
Ovarian Follicle Development
Myeloid Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Dendritic Cell Cytokine Production
Mast Cell Chemotaxis
Glycosphingolipid Metabolic Process
Inflammatory Response
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Spermatogenesis
Spermatid Development
Positive Regulation Of Cell Proliferation
Germ Cell Migration
Regulation Of Cell Shape
Visual Learning
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Positive Regulation Of Gene Expression
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Stem Cell Maintenance
Signal Transduction By Phosphorylation
Lamellipodium Assembly
Hemopoiesis
T Cell Differentiation
Erythrocyte Differentiation
Melanocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Actin Cytoskeleton Reorganization
Mast Cell Cytokine Production
Somatic Stem Cell Maintenance
Embryonic Hemopoiesis
Ectopic Germ Cell Programmed Cell Death
Megakaryocyte Development
Fc Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Kit Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
Negative Regulation Of Programmed Cell Death
Mast Cell Degranulation
Positive Regulation Of MAPK Cascade
Pigmentation
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of JAK-STAT Cascade
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Regulation Of Developmental Pigmentation
Somatic Stem Cell Division
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cell Chemotaxis
Mast Cell Differentiation
Mast Cell Proliferation
Cellular Response To Thyroid Hormone Stimulus
Melanocyte Migration
Melanocyte Adhesion
Pathways
Signaling by SCF-KIT
Signaling by Interleukins
Fc epsilon receptor (FCERI) signaling
Cytokine Signaling in Immune system
FCERI mediated Ca+2 mobilization
Interleukin-3, 5 and GM-CSF signaling
Innate Immune System
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
PIP3 activates AKT signaling
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
Regulation of KIT signaling
PI3K/AKT activation
PI-3K cascade
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Innate Immune System
Signaling by PDGF
Signalling by NGF
DAP12 interactions
GAB1 signalosome
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by ERBB4
Signaling by Overexpressed Wild-Type EGFR in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Drugs
Sorafenib
Imatinib
Dasatinib
Sunitinib
Phosphonotyrosine
Adenosine-5\'-Diphosphate
Nilotinib
Pazopanib
Regorafenib
Ponatinib
Diseases
GWAS
Crohn's disease (
23128233
)
Bipolar disorder (
19416921
)
Mean corpuscular volume (
20139978
19862010
)
Red blood cell traits (
23222517
)
Protein-Protein Interactions
30 interactors:
ARHGEF12
BMX
BTK
DOK1
ERBB2
FASLG
GNA12
IKBKG
JAK1
JAK2
KIT
LYN
PIK3R1
PIK3R2
PIK3R3
PIP4K2A
PIP5K1A
PLCG1
PLCG2
PLK4
PRLR
PTPN18
PTPN21
RHOA
SHC1
SOCS1
STAP1
TP53
VAV1
WAS
56 interactors:
ABL1
BTK
CBL
CBLB
CD81
CD9
CISH
CLTC
CRK
CRKL
CSF2RA
CSF2RB
DOK1
EPOR
FYN
GRAP
GRAP2
GRB10
GRB2
GRB7
HCK
IL7R
INPP5D
JAK2
JAK3
KITLG
LCK
LYN
MATK
MPDZ
PIK3CG
PIK3R1
PIK3R2
PLCE1
PLCG1
PRKCA
PRKCB
PTPN11
PTPN6
PTPRO
PTPRU
RASA1
SH2B2
SH2B3
SOCS1
SOCS5
SOCS6
SPRED1
SPRED2
SRC
STAP1
STAT1
STAT5A
STAT5B
TEC
YES1
Entrez ID
7006
3815
HPRD ID
02786
01287
Ensembl ID
ENSG00000135605
ENSG00000157404
Uniprot IDs
P42680
P10721
PDB IDs
2LUL
1PKG
1QZJ
1QZK
1R01
1T45
1T46
2E9W
2EC8
2VIF
3G0E
3G0F
4HVS
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Innate Immune Response
Fc Receptor Signaling Pathway
Immune Response
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Immune Response
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Signal Transduction
Wound Healing
Immune Response-regulating Signaling Pathway
Response To Organic Substance
Signaling
Defense Response
Response To Wounding
Cell Communication
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Immune System Process
Cell Activation
Regulation Of Signaling
Regulation Of Catalytic Activity
Cellular Response To Stimulus
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Growth Factor
Cell Differentiation
Cellular Response To Peptide Hormone Stimulus
Growth Hormone Receptor Signaling Pathway
Cellular Response To Peptide
Cellular Response To Growth Hormone Stimulus
Movement Of Cell Or Subcellular Component
Phagocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Regulation Of Immune Response
Regulation Of Immune System Process
Response To Peptide Hormone
Positive Regulation Of Immune System Process
Signal Transduction
Cellular Response To Organonitrogen Compound
Intracellular Signal Transduction
Cellular Response To Organic Substance
Response To Peptide
Regulation Of Body Fluid Levels
Response To Organic Substance
Immune System Process
Signaling
Regulation Of Cell Activation
Cell Communication
Cellular Response To Hormone Stimulus
Blood Coagulation
Hemostasis
Regulation Of Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Cell Activation
Positive Regulation Of Signal Transduction
Regulation Of Cell-cell Adhesion
Wound Healing
Regulation Of Signaling
Innate Immune Response
Regulation Of Cell Adhesion
Response To Organonitrogen Compound
Regulation Of Lymphocyte Activation
Response To Hormone
Immune Response-regulating Signaling Pathway
Cellular Response To Stimulus
Leukocyte Migration
Immune Response
Response To Wounding
Growth Hormone Receptor Signaling Pathway
Cellular Response To Growth Hormone Stimulus
Positive Regulation Of Immune Response
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fc Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Regulation Of T Cell Activation
Tagcloud
?
advantage
blast
blasts
cd34
clonal
clusters
colonies
continuously
csf
cytokines
granulocyte
immunomagnetic
leukemic
macrophage
microspheres
ng
physiologic
progenitor
purified
rg
rgm
ril
rm
rscf
saturating
scf
subdivided
supported
undifferentiated
Tagcloud (Difference)
?
advantage
blast
blasts
cd34
clonal
clusters
colonies
continuously
csf
cytokines
granulocyte
immunomagnetic
leukemic
macrophage
microspheres
ng
physiologic
progenitor
purified
rg
rgm
ril
rm
rscf
saturating
scf
subdivided
supported
undifferentiated
Tagcloud (Intersection)
?