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LYN and KHDRBS1
Number of citations of the paper that reports this interaction (PubMedID
7516469
)
62
Data Source:
HPRD
(in vitro)
LYN
KHDRBS1
Description
LYN proto-oncogene, Src family tyrosine kinase
KH RNA binding domain containing, signal transduction associated 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Adherens Junction
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Crista
Endocytic Vesicle Membrane
Mitochondrial Membrane
Protein-containing Complex
Integrin Alpha2-beta1 Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Protein-containing Complex
Grb2-Sos Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
SH3 Domain Binding
Enzyme Binding
Signaling Receptor Activator Activity
Ubiquitin Protein Ligase Binding
Gamma-tubulin Binding
Glycosphingolipid Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Ephrin Receptor Binding
Phosphoprotein Binding
Scaffold Protein Binding
Phosphorylation-dependent Protein Binding
Phosphatidylinositol 3-kinase Activator Activity
Nucleic Acid Binding
DNA Binding
RNA Binding
MRNA Binding
Protein Binding
Poly(A) Binding
Poly(U) RNA Binding
SH3 Domain Binding
Protein Domain Specific Binding
Signaling Adaptor Activity
SH2 Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Molecular Function Inhibitor Activity
Protein Tyrosine Kinase Binding
Biological Process
DNA Damage Checkpoint Signaling
Cell Morphogenesis
B Cell Homeostasis
Regulation Of Cytokine Production
Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Adaptive Immune Response
Immune System Process
Fc Receptor Mediated Stimulatory Signaling Pathway
Tolerance Induction To Self Antigen
Histamine Secretion By Mast Cell
Platelet Degranulation
Innate Immune Response-activating Signaling Pathway
Negative Regulation Of Myeloid Leukocyte Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Autophagy
Response To Stress
Inflammatory Response
DNA Damage Response
Response To Sterol Depletion
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Hormone
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Oligodendrocyte Development
Fatty Acid Transport
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Erythrocyte Differentiation
Eosinophil Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Neuron Projection Development
T Cell Costimulation
Lipopolysaccharide-mediated Signaling Pathway
Response To Insulin
Regulation Of Mast Cell Activation
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Interleukin-5-mediated Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
C-X-C Chemokine Receptor CXCR4 Signaling Pathway
B Cell Proliferation
Positive Regulation Of Phosphorylation
Response To Amino Acid
Regulation Of Mast Cell Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Response To Peptide Hormone
Innate Immune Response
Regulation Of Erythrocyte Differentiation
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Response To Axon Injury
Regulation Of Inflammatory Response
Negative Regulation Of Immune Response
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Negative Regulation Of Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Retinoic Acid
Cellular Response To Lipid
Regulation Of Monocyte Chemotaxis
Regulation Of Platelet Aggregation
Dendritic Cell Differentiation
Neuroinflammatory Response
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Dendritic Cell Apoptotic Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Processing
Cell Surface Receptor Signaling Pathway
Spermatogenesis
Regulation Of Protein Stability
Regulation Of Apoptotic Process
Regulation Of RNA Splicing
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Translational Initiation
Regulation Of RNA Export From Nucleus
Positive Regulation Of RNA Export From Nucleus
Regulation Of MRNA Splicing, Via Spliceosome
T Cell Receptor Signaling Pathway
Regulation Of Cell Cycle
Pathways
GPVI-mediated activation cascade
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
Co-stimulation by CD28
Co-inhibition by CTLA4
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Signaling by Erythropoietin
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Dasatinib
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Bosutinib
Ponatinib
Nintedanib
Fostamatinib
Diseases
GWAS
Granulocyte count (
27863252
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
32888494
)
Platelet count (
32888494
)
Refractive error (
32231278
)
Serum thyroid-stimulating hormone levels (
24852370
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
White blood cell count (
29403010
27863252
32888494
)
Body mass index (
26426971
)
Interacting Genes
124 interacting genes:
ACTB
ADAM15
AR
BANK1
BCAR1
BTK
CASP3
CASP7
CASP9
CBL
CBLC
CD19
CD22
CD36
CD72
CD79A
CD79B
CDK1
CDK2
CDKN1B
CHST15
COASY
CREBBP
CRKL
CSF1R
CSF2RA
CSF2RB
CSF3R
CSK
CSNK2B
CTLA4
DAPP1
DLG4
DOK1
DOK2
DOK3
EGFR
EPOR
ERBB3
ERBB4
EVL
FASLG
FCAR
FCER1G
FCGR2A
FCGR2B
FOLR1
GAB2
GAB3
GP6
GRIA3
HCLS1
HNRNPK
IGHA1
IL1B
IL2RB
IL7R
INPP5D
ITPR1
JAK2
KHDRBS1
KIT
LCP2
LIME1
MAP4K1
MAPK3
MATK
MET
MME
MS4A1
MS4A2
MUC1
NDFIP2
NEDD9
NMT1
NPHS1
PAG1
PAK2
PDE4A
PDE4D
PECAM1
PIK3CG
PILRB
PLCG1
PLCG2
PPP1R15A
PPP1R8
PRAM1
PRKCD
PRKCQ
PRKDC
PRRG4
PTK2
PTK2B
PTPN6
PTPRC
RASA1
RGS16
RPL10
RPS6KB1
RPS6KB2
SH2B2
SHC1
SKAP1
SKAP2
SLC4A1
SNCA
SOCS1
SPHK1
SPHK2
STAT3
SYK
TEC
TNF
TRAT1
TRIM28
TRIM55
TRIM63
TRIP10
TRPV4
TYK2
UBB
UHRF2
UNC119
116 interacting genes:
ABI2
ACTB
AGO1
AHI1
AMPH
APBB1
ARHGEF4
ARHGEF9
AZIN1
BAIAP2L1
BTK
CBL
CD2AP
CDC42
CDK1
CEBPA
CIRBP
CLK1
CREB3L3
CREBBP
CRK
CRKL
CSK
DDX5
DHX9
DLG1
DLG2
DLG3
DLG4
DNMBP
DOCK2
DOCK3
DSCAM
EFEMP1
EMG1
FGR
FNBP4
FRK
FXR1
FXR2
FYN
GAS7
GPHN
GRAP
GRAP2
GRB2
HCK
HNRNPK
INSR
ITK
ITPRID2
ITSN1
ITSN2
JAK3
KHDRBS3
LCK
LYN
MAPK1
MYO1C
MYO7A
NCF1
NCK1
NCK2
NCKIPSD
NPHP1
OGT
OSTF1
PACSIN1
PALS2
PIK3R1
PIK3R3
PLCG1
PLCG2
POT1
PPP1R13B
PRMT1
PSTPIP1
PTBP2
PTK6
PTPN6
RALY
RAPSN
RASA1
RBFOX2
RBM7
RUSC2
SASH1
SCG5
SH3PXD2A
SH3YL1
SHANK3
SKAP2
SMAD2
SMARCA2
SNX30
SNX9
SORBS1
SPATA13
SRC
SRPK2
STAT3
STUB1
TBL1X
TJP1
TSPOAP1
TUBB3
UBA52
UBASH3B
UBC
USP7
VAV1
WBP4
YES1
YTHDC1
ZBTB7A
ZDHHC6
Entrez ID
4067
10657
HPRD ID
01301
03926
Ensembl ID
ENSG00000254087
ENSG00000121774
Uniprot IDs
A8K379
B4DQ79
P07948
Q6NUK7
Q07666
PDB IDs
1W1F
1WA7
3A4O
5XY1
6NMW
8WFF
2XA6
3QHE
7Z89
7Z8A
7Z9A
7Z9B
7ZAB
7ZAC
7ZAF
7ZAM
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Immune System Process
Regulation Of Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Plasma Membrane
Antigen Receptor-mediated Signaling Pathway
Regulation Of Programmed Cell Death
Immune Response-activating Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Apoptotic Process
Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Activation Of Immune Response
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
B Cell Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Adaptive Immune Response
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Cell Activation
Immune Response
T Cell Receptor Signaling Pathway
Protein Kinase Activity
Negative Regulation Of Programmed Cell Death
Kinase Activity
Phosphorylation
Protein Phosphorylation
Regulation Of Multicellular Organismal Process
B Cell Activation
Regulation Of Transport
Intracellular Signaling Cassette
Negative Regulation Of Apoptotic Process
Cell Activation
Regulation Of MAPK Cascade
External Side Of Plasma Membrane
Leukocyte Activation
Regulation Of Leukocyte Proliferation
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytosol
Cytoplasm
Intracellular Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Cell-cell Junction
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Immune Response-activating Signaling Pathway
Positive Regulation Of Cellular Component Organization
Regulation Of Cellular Component Organization
Fc Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
SH3 Domain Binding
Protein Binding
Activation Of Immune Response
Regulation Of Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Plasma Membrane
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Signal Transduction
T Cell Receptor Signaling Pathway
T Cell Costimulation
Regulation Of Endocytosis
Fc-gamma Receptor Signaling Pathway
Intracellular Signaling Cassette
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Phosphorylation
Regulation Of Transport
Protein Phosphorylation
Fc Receptor Mediated Stimulatory Signaling Pathway
Ephrin Receptor Binding
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Regulation Of Vesicle-mediated Transport
Developmental Process
Regulation Of Immune Response
Immune System Process
Ionotropic Glutamate Receptor Binding
Endocytosis
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Ephrin Receptor Signaling Pathway
Tagcloud
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Tagcloud (Intersection)
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