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LYN and PIK3CG
Number of citations of the paper that reports this interaction (PubMedID
10318860
)
0
Data Source:
HPRD
(in vivo)
LYN
PIK3CG
Description
LYN proto-oncogene, Src family tyrosine kinase
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Adherens Junction
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Crista
Endocytic Vesicle Membrane
Mitochondrial Membrane
Protein-containing Complex
Integrin Alpha2-beta1 Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Phosphatidylinositol 3-kinase Complex, Class IB
Membrane
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
SH3 Domain Binding
Enzyme Binding
Signaling Receptor Activator Activity
Ubiquitin Protein Ligase Binding
Gamma-tubulin Binding
Glycosphingolipid Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Ephrin Receptor Binding
Phosphoprotein Binding
Scaffold Protein Binding
Phosphorylation-dependent Protein Binding
Phosphatidylinositol 3-kinase Activator Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Transferase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Identical Protein Binding
Ephrin Receptor Binding
1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Protein Serine Kinase Activity
Biological Process
DNA Damage Checkpoint Signaling
Cell Morphogenesis
B Cell Homeostasis
Regulation Of Cytokine Production
Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Adaptive Immune Response
Immune System Process
Fc Receptor Mediated Stimulatory Signaling Pathway
Tolerance Induction To Self Antigen
Histamine Secretion By Mast Cell
Platelet Degranulation
Innate Immune Response-activating Signaling Pathway
Negative Regulation Of Myeloid Leukocyte Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Autophagy
Response To Stress
Inflammatory Response
DNA Damage Response
Response To Sterol Depletion
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Hormone
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Oligodendrocyte Development
Fatty Acid Transport
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Erythrocyte Differentiation
Eosinophil Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Neuron Projection Development
T Cell Costimulation
Lipopolysaccharide-mediated Signaling Pathway
Response To Insulin
Regulation Of Mast Cell Activation
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Interleukin-5-mediated Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
C-X-C Chemokine Receptor CXCR4 Signaling Pathway
B Cell Proliferation
Positive Regulation Of Phosphorylation
Response To Amino Acid
Regulation Of Mast Cell Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Response To Peptide Hormone
Innate Immune Response
Regulation Of Erythrocyte Differentiation
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Response To Axon Injury
Regulation Of Inflammatory Response
Negative Regulation Of Immune Response
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Negative Regulation Of Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Retinoic Acid
Cellular Response To Lipid
Regulation Of Monocyte Chemotaxis
Regulation Of Platelet Aggregation
Dendritic Cell Differentiation
Neuroinflammatory Response
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Dendritic Cell Apoptotic Process
Angiogenesis
Positive Regulation Of Cytokine Production
Adaptive Immune Response
Immune System Process
Dendritic Cell Chemotaxis
Positive Regulation Of Acute Inflammatory Response
Respiratory Burst Involved In Defense Response
Sphingosine-1-phosphate Receptor Signaling Pathway
Lipid Metabolic Process
Endocytosis
Chemotaxis
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Endothelial Cell Migration
T Cell Chemotaxis
Negative Regulation Of Triglyceride Catabolic Process
Cell Migration
Neutrophil Chemotaxis
Secretory Granule Localization
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Rac Protein Signal Transduction
Natural Killer Cell Chemotaxis
Phosphatidylinositol-3-phosphate Biosynthetic Process
T Cell Proliferation
T Cell Activation
Mast Cell Degranulation
Positive Regulation Of MAP Kinase Activity
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Innate Immune Response
Regulation Of Angiogenesis
Phosphatidylinositol Phosphate Biosynthetic Process
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Cardiac Muscle Contraction
Platelet Aggregation
Cellular Response To CAMP
Neutrophil Extravasation
Hepatocyte Apoptotic Process
Regulation Of Calcium Ion Transmembrane Transport
Negative Regulation Of Fibroblast Apoptotic Process
Pathways
GPVI-mediated activation cascade
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
Co-stimulation by CD28
Co-inhibition by CTLA4
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Signaling by Erythropoietin
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Co-stimulation by ICOS
Drugs
Dasatinib
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Bosutinib
Ponatinib
Nintedanib
Fostamatinib
Staurosporine
Myricetin
LY-294002
Quercetin
5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE
XL765
TG100-115
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE
N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide
5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE
Wortmannin
1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Duvelisib
Fostamatinib
Diseases
GWAS
Granulocyte count (
27863252
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
32888494
)
Platelet count (
32888494
)
Refractive error (
32231278
)
Serum thyroid-stimulating hormone levels (
24852370
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
White blood cell count (
29403010
27863252
32888494
)
Antisaccade task score (
31596458
)
Blood pressure (
21909110
)
Carotid intima media thickness (
21909108
30510157
)
Carotid plaque (
30510157
)
Mean platelet volume (
22423221
19820697
22139419
28031487
24026423
)
Metabolite levels (
23823483
)
Platelet aggregation (
29185836
)
Platelet count (
22139419
22423221
29066854
29403010
)
Pulse pressure (
29403010
30487518
26390057
28739976
27841878
)
Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) (
29912962
)
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Systolic blood pressure (
28739976
27841878
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) (
29912962
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Interacting Genes
124 interacting genes:
ACTB
ADAM15
AR
BANK1
BCAR1
BTK
CASP3
CASP7
CASP9
CBL
CBLC
CD19
CD22
CD36
CD72
CD79A
CD79B
CDK1
CDK2
CDKN1B
CHST15
COASY
CREBBP
CRKL
CSF1R
CSF2RA
CSF2RB
CSF3R
CSK
CSNK2B
CTLA4
DAPP1
DLG4
DOK1
DOK2
DOK3
EGFR
EPOR
ERBB3
ERBB4
EVL
FASLG
FCAR
FCER1G
FCGR2A
FCGR2B
FOLR1
GAB2
GAB3
GP6
GRIA3
HCLS1
HNRNPK
IGHA1
IL1B
IL2RB
IL7R
INPP5D
ITPR1
JAK2
KHDRBS1
KIT
LCP2
LIME1
MAP4K1
MAPK3
MATK
MET
MME
MS4A1
MS4A2
MUC1
NDFIP2
NEDD9
NMT1
NPHS1
PAG1
PAK2
PDE4A
PDE4D
PECAM1
PIK3CG
PILRB
PLCG1
PLCG2
PPP1R15A
PPP1R8
PRAM1
PRKCD
PRKCQ
PRKDC
PRRG4
PTK2
PTK2B
PTPN6
PTPRC
RASA1
RGS16
RPL10
RPS6KB1
RPS6KB2
SH2B2
SHC1
SKAP1
SKAP2
SLC4A1
SNCA
SOCS1
SPHK1
SPHK2
STAT3
SYK
TEC
TNF
TRAT1
TRIM28
TRIM55
TRIM63
TRIP10
TRPV4
TYK2
UBB
UHRF2
UNC119
22 interacting genes:
CD28
EPHA8
GAB1
GRB2
GRK2
GSN
HRAS
IL6ST
KIT
KRAS
LYN
NOTCH1
NRAS
PIK3CD
PIK3R5
PIK3R6
PTPN11
SEC14L2
SET
SMPD2
TPM2
ZNF282
Entrez ID
4067
5294
HPRD ID
01301
03135
Ensembl ID
ENSG00000254087
ENSG00000105851
Uniprot IDs
A8K379
B4DQ79
P07948
Q6NUK7
A8K9G9
P48736
PDB IDs
1W1F
1WA7
3A4O
5XY1
6NMW
8WFF
1E8Y
1E8Z
1HE8
2A4Z
2A5U
2CHW
2CHX
2CHZ
2V4L
3APC
3APD
3APF
3CSF
3CST
3DBS
3DPD
3ENE
3IBE
3L08
3L13
3L16
3L17
3L54
3LJ3
3MJW
3ML8
3ML9
3NZS
3NZU
3OAW
3P2B
3PRE
3PRZ
3PS6
3QAQ
3QAR
3QJZ
3QK0
3R7Q
3R7R
3S2A
3SD5
3T8M
3TJP
3TL5
3ZVV
3ZW3
4ANU
4ANV
4ANW
4ANX
4AOF
4DK5
4EZJ
4EZK
4EZL
4F1S
4FA6
4FAD
4FHJ
4FHK
4FJY
4FJZ
4FLH
4FUL
4G11
4GB9
4HLE
4HVB
4J6I
4KZ0
4KZC
4PS3
4PS7
4PS8
4URK
4WWN
4WWO
4WWP
4XX5
4XZ4
5EDS
5G2N
5G55
5JHA
5JHB
5KAE
5OQ4
5T23
6AUD
6C1S
6FH5
6GQ7
6T3B
6T3C
6XRL
6XRM
6XRN
7JWE
7JWZ
7JX0
7KKE
7MEZ
7Z61
8DP0
8SC8
9GG9
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Immune System Process
Regulation Of Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Plasma Membrane
Antigen Receptor-mediated Signaling Pathway
Regulation Of Programmed Cell Death
Immune Response-activating Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Apoptotic Process
Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Activation Of Immune Response
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
B Cell Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Adaptive Immune Response
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Cell Activation
Immune Response
T Cell Receptor Signaling Pathway
Protein Kinase Activity
Negative Regulation Of Programmed Cell Death
Kinase Activity
Phosphorylation
Protein Phosphorylation
Regulation Of Multicellular Organismal Process
B Cell Activation
Regulation Of Transport
Intracellular Signaling Cassette
Negative Regulation Of Apoptotic Process
Cell Activation
Regulation Of MAPK Cascade
External Side Of Plasma Membrane
Leukocyte Activation
Regulation Of Leukocyte Proliferation
T Cell Costimulation
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of MAPK Cascade
Regulation Of MAPK Cascade
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Signal Transduction
Phosphatidylinositol 3-kinase Complex
Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Phosphatidylinositol 3-kinase Complex, Class IA
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Signal Transduction
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell Communication
Regulation Of Cell Adhesion
Regulation Of T Cell Activation
Intracellular Signal Transduction
Positive Regulation Of Signaling
Positive Regulation Of Cell Activation
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Glial Cell Development
Positive Regulation Of Gliogenesis
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Adhesion
Regulation Of Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Ras Protein Signal Transduction
Regulation Of Multicellular Organismal Development
Response To Mechanical Stimulus
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Programmed Cell Death
Immune System Process
Plasma Membrane
Cell Development
Immune Response
Regulation Of Gliogenesis
Positive Regulation Of Gene Expression
Positive Regulation Of Neurogenesis
Regulated Exocytosis
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Tagcloud (Difference)
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Tagcloud (Intersection)
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