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TEC and ERBB2
Number of citations of the paper that reports this interaction (PMID
16273093
)
170
Data Source:
BioGRID
(unspecified method)
TEC
ERBB2
Gene Name
tec protein tyrosine kinase
erb-b2 receptor tyrosine kinase 2
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoskeleton
Cell-cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Nucleus
Cytoplasm
Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle
Receptor Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Lipid Binding
Metal Ion Binding
RNA Polymerase I Core Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Receptor Signaling Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Growth Factor Binding
Protein Phosphatase Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
Biological Process
Adaptive Immune Response
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Platelet Activation
Cell Differentiation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Proliferation
Tissue Regeneration
Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Transcription, DNA-templated
Protein Phosphorylation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Peripheral Nervous System Development
Heart Development
Neuromuscular Junction Development
Motor Neuron Axon Guidance
Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Signal Transduction By Phosphorylation
Positive Regulation Of Cell Growth
Positive Regulation Of Rho GTPase Activity
Regulation Of Microtubule-based Process
Negative Regulation Of Immature T Cell Proliferation In Thymus
Fc-epsilon Receptor Signaling Pathway
Wound Healing
Myelination
Positive Regulation Of MAP Kinase Activity
Innate Immune Response
Positive Regulation Of Translation
Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription From RNA Polymerase I Promoter
Positive Regulation Of Transcription From RNA Polymerase III Promoter
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of ERK1 And ERK2 Cascade
Pathways
Signaling by SCF-KIT
Signaling by Interleukins
Fc epsilon receptor (FCERI) signaling
Cytokine Signaling in Immune system
FCERI mediated Ca+2 mobilization
Interleukin-3, 5 and GM-CSF signaling
Innate Immune System
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
Axon guidance
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Signaling by EGFRvIII in Cancer
PLCG1 events in ERBB2 signaling
Signaling by SCF-KIT
SHC1 events in ERBB2 signaling
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Sema4D in semaphorin signaling
Sema4D induced cell migration and growth-cone collapse
Innate Immune System
Signaling by PDGF
Downregulation of ERBB2:ERBB3 signaling
Signalling by NGF
DAP12 interactions
GAB1 signalosome
Semaphorin interactions
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by ERBB4
Signaling by Overexpressed Wild-Type EGFR in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Drugs
Trastuzumab
Lapatinib
ado-trastuzumab emtansine
Pertuzumab
Afatinib
Diseases
GWAS
Crohn's disease (
23128233
)
Protein-Protein Interactions
30 interactors:
ARHGEF12
BMX
BTK
DOK1
ERBB2
FASLG
GNA12
IKBKG
JAK1
JAK2
KIT
LYN
PIK3R1
PIK3R2
PIK3R3
PIP4K2A
PIP5K1A
PLCG1
PLCG2
PLK4
PRLR
PTPN18
PTPN21
RHOA
SHC1
SOCS1
STAP1
TP53
VAV1
WAS
110 interactors:
ABL1
ABL2
ACPP
ANKS1A
ANKS1B
APBB1
APBB3
BCAR3
BLK
BLNK
BMX
BTC
CAV1
CBL
CD82
CHN1
CISH
CLNK
CRK
CRKL
CTNNB1
DAB1
DLG4
DOK1
DOK4
DOK6
EGF
EGFR
ERBB2IP
ERBB3
ERBB4
ERRFI1
ESR1
FER
FGR
GRAP2
GRB2
GRB7
HDAC6
HLA-A
HSP90AA1
HSP90B1
IL6ST
IRS1
IRS4
ITGA5
ITGB4
ITK
JAK1
JAK2
JUP
MAPK8IP1
MAPK8IP2
MATK
MUC1
MUC4
NCK2
NF2
NRG1
PAK1
PICK1
PIK3C2A
PIK3C2B
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PTK2
PTK2B
PTPN11
PTPN18
RASA1
RIN1
RIN2
SERPINA3
SH2B2
SH2B3
SH2D1B
SH2D2A
SH2D3A
SH2D5
SH3BGRL3
SH3BP2
SHC1
SHC2
SHC3
SLA
SLA2
SOCS1
SOS1
SRC
SRPK1
STAT1
STAT3
STUB1
SUPT6H
SYK
TEC
TGFA
TLN1
TNS2
TNS3
TOB1
TXK
UBB
USP2
VAV1
VAV2
VAV3
Entrez ID
7006
2064
HPRD ID
02786
01281
Ensembl ID
ENSG00000135605
ENSG00000141736
Uniprot IDs
P42680
P04626
PDB IDs
2LUL
1MFG
1MFL
1MW4
1N8Z
1OVC
1QR1
1S78
2A91
2JWA
2KS1
2L4K
3BE1
3H3B
3MZW
3N85
3PP0
3RCD
4GFU
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Innate Immune Response
Fc Receptor Signaling Pathway
Immune Response
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Immune Response
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Signal Transduction
Wound Healing
Immune Response-regulating Signaling Pathway
Response To Organic Substance
Signaling
Defense Response
Response To Wounding
Cell Communication
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Immune System Process
Cell Activation
Regulation Of Signaling
Regulation Of Catalytic Activity
Cellular Response To Stimulus
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Growth Factor
Cell Differentiation
Cellular Response To Peptide Hormone Stimulus
Growth Hormone Receptor Signaling Pathway
Cellular Response To Peptide
Cellular Response To Growth Hormone Stimulus
Movement Of Cell Or Subcellular Component
Phagocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Signal Transduction
Cell Communication
Signaling
Cell Surface Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Cellular Response To Stimulus
Intracellular Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Response To Stimulus
Regulation Of Immune Response
Fc Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Immune Response
Regulation Of Immune System Process
Defense Response
Immune System Process
Cellular Response To Organic Substance
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Response To Stress
Peptidyl-tyrosine Autophosphorylation
Regulation Of Catalytic Activity
Response To Organic Substance
Cellular Response To Organonitrogen Compound
Fc-epsilon Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Regulation Of Cellular Process
Cellular Response To Peptide
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Locomotion
Neurotrophin Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Catalytic Activity
Movement Of Cell Or Subcellular Component
Cell Motility
Cell Migration
Wound Healing
Response To Peptide Hormone
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Tagcloud
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Difference)
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Intersection)
?