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TEC and PLCG2
Number of citations of the paper that reports this interaction (PMID
15184383
)
18
Data Source:
HPRD
(in vitro)
TEC
PLCG2
Gene Name
tec protein tyrosine kinase
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoskeleton
Cell-cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cytosol
Plasma Membrane
Extracellular Vesicular Exosome
Molecular Function
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Lipid Binding
Metal Ion Binding
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Signal Transducer Activity
Protein Binding
Biological Process
Adaptive Immune Response
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Platelet Activation
Cell Differentiation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Proliferation
Tissue Regeneration
Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Follicular B Cell Differentiation
Phosphatidylinositol Biosynthetic Process
Blood Coagulation
Phospholipid Catabolic Process
Regulation Of Gene Expression
Wnt Signaling Pathway
Calcium-mediated Signaling
Platelet Activation
B Cell Differentiation
Activation Of Store-operated Calcium Channel Activity
Response To Lipopolysaccharide
Inositol Trisphosphate Biosynthetic Process
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Programmed Cell Death
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Pathways
Signaling by SCF-KIT
Signaling by Interleukins
Fc epsilon receptor (FCERI) signaling
Cytokine Signaling in Immune system
FCERI mediated Ca+2 mobilization
Interleukin-3, 5 and GM-CSF signaling
Innate Immune System
Signaling by the B Cell Receptor (BCR)
DAP12 interactions
FCERI mediated MAPK activation
Inositol phosphate metabolism
DAP12 signaling
Toll-Like Receptors Cascades
Synthesis of IP3 and IP4 in the cytosol
Toll Like Receptor 4 (TLR4) Cascade
Role of phospholipids in phagocytosis
GPVI-mediated activation cascade
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
Fcgamma receptor (FCGR) dependent phagocytosis
Platelet activation, signaling and aggregation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Adaptive Immune System
Innate Immune System
Drugs
Diseases
GWAS
Crohn's disease (
23128233
)
Protein-Protein Interactions
30 interactors:
ARHGEF12
BMX
BTK
DOK1
ERBB2
FASLG
GNA12
IKBKG
JAK1
JAK2
KIT
LYN
PIK3R1
PIK3R2
PIK3R3
PIP4K2A
PIP5K1A
PLCG1
PLCG2
PLK4
PRLR
PTPN18
PTPN21
RHOA
SHC1
SOCS1
STAP1
TP53
VAV1
WAS
34 interactors:
BLK
BLNK
BTK
CBLB
CD19
DAPP1
EGFR
EPOR
ERBB2
FCER1G
FLT1
FYN
GAB1
GAB2
HCK
IRS1
ITK
JAK1
JAK2
KDR
KHDRBS1
LAT
LAT2
LCK
LCP2
LIME1
LYN
NPM1
PRKD1
SH3BP2
SHC1
SYK
TEC
ZNF512B
Entrez ID
7006
5336
HPRD ID
02786
02570
Ensembl ID
ENSG00000135605
ENSG00000197943
Uniprot IDs
P42680
P16885
PDB IDs
2LUL
2K2J
2W2W
2W2X
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Innate Immune Response
Fc Receptor Signaling Pathway
Immune Response
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Immune Response
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Signal Transduction
Wound Healing
Immune Response-regulating Signaling Pathway
Response To Organic Substance
Signaling
Defense Response
Response To Wounding
Cell Communication
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Immune System Process
Cell Activation
Regulation Of Signaling
Regulation Of Catalytic Activity
Cellular Response To Stimulus
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Growth Factor
Cell Differentiation
Cellular Response To Peptide Hormone Stimulus
Growth Hormone Receptor Signaling Pathway
Cellular Response To Peptide
Cellular Response To Growth Hormone Stimulus
Movement Of Cell Or Subcellular Component
Phagocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Innate Immune Response
Peptidyl-tyrosine Autophosphorylation
Regulation Of Immune Response
Enzyme Linked Receptor Protein Signaling Pathway
Immune Response
Protein Autophosphorylation
Immune System Process
Regulation Of Immune System Process
Peptidyl-tyrosine Phosphorylation
Defense Response
Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Signaling
Cell Communication
B Cell Receptor Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Stimulus
Regulation Of Cell Proliferation
Positive Regulation Of Immune Response
Positive Regulation Of Immune System Process
Peptidyl-amino Acid Modification
Cell Activation
Positive Regulation Of Signal Transduction
Response To Stimulus
Response To Stress
Leukocyte Activation
Protein Phosphorylation
Cellular Response To Organic Substance
Response To Organic Substance
Regulation Of Cell Activation
Cell Migration
Locomotion
Phosphorylation
Cell Motility
Mast Cell Activation
Phosphatidylinositol-mediated Signaling
Wound Healing
Leukocyte Migration
Movement Of Cell Or Subcellular Component
Regulation Of Signaling
Regulation Of Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Tagcloud
?
16x10
associations
chrne
comprehensively
dysregulated
escc
esccs
esophageal
fyn
gc
gcs
germline
gnai3
han
itch
map2k1
map2k4
mapk8
observe
pak4
pik3r3
prlr
rank
resampling
rps6kb2
tln1
validate
warranted
wasl
Tagcloud (Difference)
?
16x10
associations
chrne
comprehensively
dysregulated
escc
esccs
esophageal
fyn
gc
gcs
germline
gnai3
han
itch
map2k1
map2k4
mapk8
observe
pak4
pik3r3
prlr
rank
resampling
rps6kb2
tln1
validate
warranted
wasl
Tagcloud (Intersection)
?