ACTR2 and FCGR2A

		ACTR2	FCGR2A
Description		actin related protein 2	Fc gamma receptor IIa
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Protein Binding IgG Receptor Activity IgG Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Actin Cytoskeleton Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Antibody-dependent Cellular Cytotoxicity Immune System Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Calcific aortic valve stenosis ( 32141789) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 33772158 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 26663301 28714469 27399966 26502338 24871463) Takayasu arteritis ( 23830517) Ulcerative colitis ( 28067908 19915573 21297633 20228799)
Interacting Genes		19 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CEBPA ELF5 ERCC6 FILNC1 HCLS1 IQGAP2 LINC00632 PLK4 SHARPIN WAS WASF1 WASF2 WASL	26 interacting genes: ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LYN MIP NSG1 PIK3R1 SERP2 SHC1 SYK UBQLN1 UPK2
Entrez ID		10097	2212
HPRD ID		05023	00906
Ensembl ID		ENSG00000138071	ENSG00000143226
Uniprot IDs		P61160	A0A8V8TPS4 P12318
PDB IDs		6UHC 6YW6 6YW7 8P94	1FCG 1H9V 3D5O 3RY4 3RY5 3RY6 8CHA
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Cytoskeleton Arp2/3 Complex-mediated Actin Nucleation Supramolecular Fiber Organization Actin Nucleation Actin Binding Arp2/3 Protein Complex Lamellipodium Actin Filament Polymerization Actin Filament Binding Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Filament-based Movement Regulation Of Cytoskeleton Organization Cytoskeleton Protein Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Actin Filament-based Process Site Of Double-strand Break Structural Constituent Of Cytoskeleton Regulation Of Actin Filament Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization SCAR Complex Positive Regulation Of Actin Nucleation Focal Adhesion Trophoblast Giant Cell Differentiation Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Rac Protein Signal Transduction Protein Kinase A Binding GTPase Regulator Activity	Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Signaling Pathway Leukocyte Degranulation Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Regulated Exocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Immune Response Cell Activation IgE Binding Negative Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Lymphocyte Mediated Immunity Fc-epsilon Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Leukocyte Activation Mast Cell Degranulation Exocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Membrane Defense Response Negative Regulation Of Immune Response Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Mediated Immunity Immune Response-activating Signaling Pathway Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Hypersensitivity Immunoglobulin Mediated Immune Response Secretion By Cell Response To Other Organism Regulation Of Transport Activation Of Immune Response IgG Binding Defense Response To Symbiont B Cell Mediated Immunity
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