ACTR2 and ARPC5

Number of citations of the paper that reports this interaction (PMID 11721045)
137

Data Source:
HPRD (in vitro)

		ACTR2	ARPC5
Gene Name		ARP2 actin-related protein 2 homolog (yeast)	actin related protein 2/3 complex, subunit 5, 16kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Actin Cap Cell Projection Extracellular Vesicular Exosome	Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton ATP Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Movement Of Cell Or Subcellular Component Establishment Or Maintenance Of Cell Polarity Axon Guidance Asymmetric Cell Division Meiotic Chromosome Movement Towards Spindle Pole Cytoplasmic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cilium Assembly Innate Immune Response Ephrin Receptor Signaling Pathway Spindle Localization	Movement Of Cell Or Subcellular Component Axon Guidance Actin Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CTTN ELF5 HCLS1 IQGAP2 WASF1 WASF2 WASL	6 interactors: ACTR2 ACTR3 ARPC1B ARPC4 MAPKAPK2 NR3C1
Entrez ID		10097	10092
HPRD ID		05023	11969
Ensembl ID		ENSG00000138071	ENSG00000162704
Uniprot IDs		P61160	O15511
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Organelle Organization Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Actin Nucleation Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Actin Polymerization Or Depolymerization Actin Filament Polymerization Movement Of Cell Or Subcellular Component Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Ephrin Receptor Signaling Pathway Protein Polymerization Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Endocytosis Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process System Development Actin Filament-based Movement Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Morphogenesis Positive Regulation Of Immune Response	Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Meiotic Chromosome Movement Towards Spindle Pole Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Asymmetric Cell Division Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Meiotic Cytokinesis Ephrin Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Actin Filament-based Process Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Regulation Of Immune Response Phagocytosis Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Establishment Of Chromosome Localization Cytoskeleton Organization Spindle Localization Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Immune Response Regulation Of Immune System Process Defense Response Meiotic Chromosome Segregation Vesicle-mediated Transport Axonogenesis Movement Of Cell Or Subcellular Component
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