ACTR2 and BMP2

Number of citations: 54 (PubMedID 10880444)
Data Source: BioGRID (pull down)

		ACTR2	BMP2
Name		actin related protein 2	bone morphogenetic protein 2
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Plasma Membrane Cilium Cell Surface BMP Receptor Complex Enzyme Activator Complex
	Molecular Function	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Phosphatase Activator Activity Co-receptor Binding Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity BMP Receptor Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Actin Cytoskeleton Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Chondrocyte Differentiation Myeloid Leukocyte Differentiation Heart Morphogenesis Heart Induction Endodermal-mesodermal Cell Signaling Aortic Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Atrium Formation Endocardial Cushion Formation Positive Regulation Of Extracellular Matrix Constituent Secretion Proteoglycan Metabolic Process Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Bacterium Animal Organ Morphogenesis Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Negative Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Protein Destabilization Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Cell Proliferation Astrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Negative Regulation Of Muscle Cell Differentiation Cartilage Development Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Bone Development Positive Regulation Of SMAD Protein Signal Transduction Lung Vasculature Development Mesenchyme Development Muscle Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Odontoblast Differentiation Positive Regulation Of MiRNA Transcription Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cortisol Biosynthetic Process Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Signaling by BMP Molecules associated with elastic fibres Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	None
GWAS		Calcific aortic valve stenosis ( 32141789 ) Coronary artery disease ( 29212778 33020668 ) Heel bone mineral density ( 30598549 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Metabolite levels ( 23823483 )	Adult body size ( 32376654 ) Atrial fibrillation ( 29892015 ) Axial length ( 24144296 ) Body mass index ( 19079261 25673413 23669352 28892062 ) Body size at age 10 ( 32376654 ) Childhood ear infection ( 27182965 ) Colorectal cancer ( 23266556 29471430 24737748 30529582 31826910 25990418 26151821 ) Colorectal cancer or advanced adenoma ( 30510241 ) Copper levels ( 26025379 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) FEV1 ( 30804560 ) Heel bone mineral density ( 30598549 28869591 ) Height ( 31562340 25429064 25282103 23563607 18391951 20881960 ) Hip circumference adjusted for BMI ( 25673412 ) Lung function (FVC) ( 30804560 28166213 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Major depressive disorder (stressful life events interaction) ( 26845276 ) Mitochondrial heteroplasmy measurement ( 33731350 ) Nose morphology (partial least square model) ( 30174134 ) Obesity-related traits ( 23251661 ) Optic cup area ( 25631615 31798171 28073927 ) Peak expiratory flow ( 30804560 ) Pulse pressure ( 30224653 ) QRS complex (Cornell) ( 27659466 ) Refractive error ( 23396134 32231278 ) Retinal detachment or retinal break ( 31816047 ) Sagittal craniosynostosis ( 23160099 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Triglyceride levels x loop diuretics use interaction ( 31806883 ) Vertical cup-disc ratio ( 28073927 25241763 31798171 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 28448500 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500 )
Novel Interactors		1 novel interactors: FCGR2A	None recorded
Interacting Genes		19 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CEBPA ELF5 ERCC6 FILNC1 HCLS1 IQGAP2 LINC00632 PLK4 SHARPIN WAS WASF1 WASF2 WASL	21 interacting genes: ACTR2 ACVR1 ACVR2A ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG RGMB SOSTDC1 TGFB1 TGFB2
Entrez ID		10097	650
HPRD ID		05023	00206
Ensembl ID		ENSG00000138071	ENSG00000125845
Uniprot IDs		P61160	C8C060 P12643
PDB IDs		6UHC 6YW6 6YW7 8P94	1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP 4MID 4N1D 4UHY 4UHZ 4UI0 4UI1 4UI2 6OMN 7AG0 8E3G
GO Terms Enriched among Interactors		Actin Filament Organization Actin Cytoskeleton Arp2/3 Complex-mediated Actin Nucleation Supramolecular Fiber Organization Actin Nucleation Actin Binding Arp2/3 Protein Complex Lamellipodium Actin Filament Polymerization Actin Filament Binding Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Filament-based Movement Regulation Of Cytoskeleton Organization Cytoskeleton Protein Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Actin Filament-based Process Site Of Double-strand Break Structural Constituent Of Cytoskeleton Regulation Of Actin Filament Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization SCAR Complex Positive Regulation Of Actin Nucleation Focal Adhesion Trophoblast Giant Cell Differentiation Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Rac Protein Signal Transduction Protein Kinase A Binding GTPase Regulator Activity	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway BMP Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Binding Regulation Of SMAD Protein Signal Transduction BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To BMP Stimulus Pattern Specification Process Regulation Of Ossification Response To Growth Factor Regulation Of Bone Mineralization Regulation Of Osteoblast Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Regulation Of BMP Signaling Pathway System Development Dorsal/ventral Pattern Formation Negative Regulation Of BMP Signaling Pathway Animal Organ Morphogenesis Tissue Development Positive Regulation Of Bone Mineralization Regulation Of Signal Transduction Embryonic Morphogenesis Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Animal Organ Development Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Differentiation Outflow Tract Septum Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Activin Receptor Signaling Pathway Regulation Of Developmental Process Cardiac Septum Morphogenesis Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Positive Regulation Of Developmental Process Activin Binding Pharyngeal Arch Artery Morphogenesis Ventricular Septum Morphogenesis Activin Receptor Activity, Type II