ACTR2 and SHARPIN

Number of citations of the paper that reports this interaction (PubMedID 28775156)
66

Data Source:
BioGRID (pull down)

		ACTR2	SHARPIN
Description		actin related protein 2	SHANK associated RH domain interactor
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Synapse LUBAC Complex
	Molecular Function	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Actin Cytoskeleton Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Mitochondrion Organization Epidermis Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Apoptotic Nuclear Changes Keratinization Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Neurexins and neuroligins
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Calcific aortic valve stenosis ( 32141789) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)	Asthma ( 31959851 32296059) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		19 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CEBPA ELF5 ERCC6 FILNC1 HCLS1 IQGAP2 LINC00632 PLK4 SHARPIN WAS WASF1 WASF2 WASL	30 interacting genes: ACTR2 ACTR3 FMR1 FXR1 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 PTEN RBCK1 RNF26 RNF31 SHANK1 SHANK2 SHANK3 TIAM1 TNF TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32
Entrez ID		10097	81858
HPRD ID		05023	15463
Ensembl ID		ENSG00000138071	ENSG00000179526
Uniprot IDs		P61160	Q6PJD5 Q9H0F6
PDB IDs		6UHC 6YW6 6YW7 8P94	4EMO 5X0W 8K6P
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Cytoskeleton Arp2/3 Complex-mediated Actin Nucleation Supramolecular Fiber Organization Actin Nucleation Actin Binding Arp2/3 Protein Complex Lamellipodium Actin Filament Polymerization Actin Filament Binding Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Filament-based Movement Regulation Of Cytoskeleton Organization Cytoskeleton Protein Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Actin Filament-based Process Site Of Double-strand Break Structural Constituent Of Cytoskeleton Regulation Of Actin Filament Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization SCAR Complex Positive Regulation Of Actin Nucleation Focal Adhesion Trophoblast Giant Cell Differentiation Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Rac Protein Signal Transduction Protein Kinase A Binding GTPase Regulator Activity	Integrin Complex Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Synaptic Receptor Adaptor Activity Cellular Extravasation Dendritic Spine Positive Regulation Of Long-term Neuronal Synaptic Plasticity Heterotypic Cell-cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Nervous System Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Social Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Signaling Receptor Activity Vocalization Behavior Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Meiotic Chromosome Movement Towards Spindle Pole Cell Adhesion Cell Surface Postsynaptic Specialization Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dopamine Metabolic Process Microglial Cell Activation LUBAC Complex Ionotropic Glutamate Receptor Binding Neuron Projection Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane RNA Strand Annealing Activity Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Positive Regulation Of Dendritic Spine Development Positive Regulation Of DNA-binding Transcription Factor Activity Postsynaptic Membrane Signal Transduction Intracellular Membraneless Organelle Regulation Of Neutrophil Degranulation
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