ACTR2 and ACTR3

Number of citations of the paper that reports this interaction (PMID 11721045)
137

Data Source:
HPRD (in vitro, in vivo)

		ACTR2	ACTR3
Gene Name		ARP2 actin-related protein 2 homolog (yeast)	ARP3 actin-related protein 3 homolog (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Actin Cap Cell Projection Extracellular Vesicular Exosome	Golgi Membrane Podosome Cytosol Actin Filament Arp2/3 Protein Complex Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Hemidesmosome Excitatory Synapse Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton ATP Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Movement Of Cell Or Subcellular Component Establishment Or Maintenance Of Cell Polarity Axon Guidance Asymmetric Cell Division Meiotic Chromosome Movement Towards Spindle Pole Cytoplasmic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cilium Assembly Innate Immune Response Ephrin Receptor Signaling Pathway Spindle Localization	Movement Of Cell Or Subcellular Component Establishment Or Maintenance Of Cell Polarity Axon Guidance Asymmetric Cell Division Response To Carbohydrate Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Myosin II Filament Organization Innate Immune Response Response To Antibiotic Ephrin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Filopodium Assembly Spindle Localization Cilium Morphogenesis
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CTTN ELF5 HCLS1 IQGAP2 WASF1 WASF2 WASL	13 interactors: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN HCLS1 JUND WASF2 WASF3 WASL
Entrez ID		10097	10096
HPRD ID		05023	05024
Ensembl ID		ENSG00000138071	ENSG00000115091
Uniprot IDs		P61160	B4DXW1 P61158
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Organelle Organization Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Actin Nucleation Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Actin Polymerization Or Depolymerization Actin Filament Polymerization Movement Of Cell Or Subcellular Component Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Ephrin Receptor Signaling Pathway Protein Polymerization Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Endocytosis Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process System Development Actin Filament-based Movement Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Morphogenesis Positive Regulation Of Immune Response	Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Organelle Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Actin Filament-based Process Cytoskeleton Organization Phagocytosis Cell Projection Organization Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Development Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Organelle Organization Positive Regulation Of Actin Filament Polymerization Cell Morphogenesis Cell Differentiation Positive Regulation Of Protein Polymerization Immune Response-regulating Signaling Pathway Neuron Projection Development Cell Projection Morphogenesis Actin Nucleation Regulation Of Immune System Process Cell Part Morphogenesis Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cellular Component Size Positive Regulation Of Protein Complex Assembly Neuron Development Positive Regulation Of Immune Response Neuron Projection Morphogenesis Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Actin Polymerization Or Depolymerization Neurogenesis
Tagcloud ?			actb anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours wdr1
Tagcloud (Difference) ?			actb anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours wdr1
Tagcloud (Intersection) ?