ACTR2 and HCLS1

Number of citations of the paper that reports this interaction (PMID 12534372)
19

Data Source:
HPRD (in vitro)

		ACTR2	HCLS1
Gene Name		ARP2 actin-related protein 2 homolog (yeast)	hematopoietic cell-specific Lyn substrate 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Actin Cap Cell Projection Extracellular Vesicular Exosome	Nucleus Transcription Factor Complex Cytoplasm Mitochondrion Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton ATP Binding Actin Filament Binding	RNA Polymerase II Transcription Factor Binding Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Complex Binding
	Biological Process	Movement Of Cell Or Subcellular Component Establishment Or Maintenance Of Cell Polarity Axon Guidance Asymmetric Cell Division Meiotic Chromosome Movement Towards Spindle Pole Cytoplasmic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cilium Assembly Innate Immune Response Ephrin Receptor Signaling Pathway Spindle Localization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CTTN ELF5 HCLS1 IQGAP2 WASF1 WASF2 WASL	23 interactors: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SSBP3 SYK TERF1 TRIM29 WAS ZBTB25
Entrez ID		10097	3059
HPRD ID		05023	03199
Ensembl ID		ENSG00000138071	ENSG00000180353
Uniprot IDs		P61160	E7EVW7 P14317
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Organelle Organization Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Actin Nucleation Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Actin Polymerization Or Depolymerization Actin Filament Polymerization Movement Of Cell Or Subcellular Component Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Ephrin Receptor Signaling Pathway Protein Polymerization Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Endocytosis Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process System Development Actin Filament-based Movement Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Morphogenesis Positive Regulation Of Immune Response	Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Phagocytosis Regulation Of Immune System Process Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Innate Immune Response Immune System Process Positive Regulation Of Organelle Organization Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Mast Cell Degranulation Meiotic Chromosome Movement Towards Spindle Pole Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Polymerization B Cell Homeostasis Regulation Of Mast Cell Activation Regulation Of Cytoskeleton Organization Regulation Of Regulated Secretory Pathway Regulation Of Cellular Process B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Developmental Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Asymmetric Cell Division Immune Response Regulation Of Organelle Organization Regulation Of Phosphorylation Chemotaxis Defense Response Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Complex Assembly Response To External Stimulus
Tagcloud ?			actn1 candidates clonogenic gap gy integration integrin itgb5 junction junctions microarray microarrays nci overrepresented pfn2 platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?			actn1 candidates clonogenic gap gy integration integrin itgb5 junction junctions microarray microarrays nci overrepresented pfn2 platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?