ACTR2 and HCLS1

Number of citations of the paper that reports this interaction (PubMedID 12534372)
45

Data Source:
HPRD (in vitro)

		ACTR2	HCLS1
Description		actin related protein 2	hematopoietic cell-specific Lyn substrate 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Adaptor Activity Protein-containing Complex Binding Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Actin Cytoskeleton Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Intracellular Signal Transduction Granulocyte Colony-stimulating Factor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Calcific aortic valve stenosis ( 32141789) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CEBPA ELF5 ERCC6 FILNC1 HCLS1 IQGAP2 LINC00632 PLK4 SHARPIN WAS WASF1 WASF2 WASL	25 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CRYAA CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25
Entrez ID		10097	3059
HPRD ID		05023	03199
Ensembl ID		ENSG00000138071	ENSG00000180353
Uniprot IDs		P61160	E7EVW7 P14317
PDB IDs		6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Cytoskeleton Arp2/3 Complex-mediated Actin Nucleation Supramolecular Fiber Organization Actin Nucleation Actin Binding Arp2/3 Protein Complex Lamellipodium Actin Filament Polymerization Actin Filament Binding Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Filament-based Movement Regulation Of Cytoskeleton Organization Cytoskeleton Protein Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Actin Filament-based Process Site Of Double-strand Break Structural Constituent Of Cytoskeleton Regulation Of Actin Filament Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization SCAR Complex Positive Regulation Of Actin Nucleation Focal Adhesion Trophoblast Giant Cell Differentiation Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Rac Protein Signal Transduction Protein Kinase A Binding GTPase Regulator Activity	B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Actin Cytoskeleton Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Meiotic Chromosome Movement Towards Spindle Pole B Cell Homeostasis Immune Response-activating Signaling Pathway Regulation Of Mast Cell Degranulation B Cell Receptor Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Metabolic Process Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Lamellipodium Assembly Positive Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Actin Filament Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Meiotic Cytokinesis Fc Receptor Signaling Pathway Arp2/3 Protein Complex Negative Regulation Of Immune System Process Lymphocyte Homeostasis Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Type II Interferon Asymmetric Cell Division Regulation Of Autophagy Leukocyte Homeostasis Immune Response Positive Regulation Of Mast Cell Degranulation Chromosome Localization Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Immune Response Innate Immune Response Negative Regulation Of B Cell Proliferation Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Cellular Component Organization
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