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TBL1X and TINF2
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
TBL1X
TINF2
Description
transducin beta like 1 X-linked
TERF1 interacting nuclear factor 2
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Transcription Repressor Complex
Mitotic Spindle
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Perinucleolar Chromocenter
Nuclear Matrix
Nuclear Body
Shelterin Complex
Molecular Function
Transcription Cis-regulatory Region Binding
Transcription Corepressor Activity
Protein Binding
Histone Binding
Identical Protein Binding
DNA Binding
Protein Binding
Telomeric DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Proteolysis
Sensory Perception Of Sound
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Positive Regulation Of Canonical Wnt Signaling Pathway
Telomere Capping
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Epithelial Cell Proliferation
Protein Localization To Chromosome, Telomeric Region
Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways
BMAL1:CLOCK,NPAS2 activates circadian expression
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by PPARalpha
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
Cytoprotection by HMOX1
Heme signaling
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS
Prostate cancer (
23535732
)
Refractive error (
32231278
)
Leukocyte telomere length (
31171785
)
Platelet count (
29403010
)
Interacting Genes
31 interacting genes:
ARL2
ARL3
CDC34
CORO2A
CTNNB1
DDB1
DLX3
DNAJB4
FOXK2
GPS2
H2AC18
H2BC21
H3C14
H4C1
H4C14
HDAC3
HP
HR
KHDRBS1
MECP2
NCOR1
NCOR2
SKP1
TAB2
TBL1XR1
TERF1
THRA
THRB
TINF2
UBE2D1
UBE2I
91 interacting genes:
ACD
ACOT7
ACTB
ADA
AFAP1L2
AIPL1
AK1
ANKMY2
ANXA4
ANXA5
ANXA8L1
APOBEC3F
APPL2
ARHGDIA
ARID3B
BAG3
BIN2
CALD1
CCDC43
CCDC9
CKB
CLK3
CPNE3
CRYGS
CSNK2A1
CTTN
DBN1
DCX
DHFR2
DPP3
EEF1D
EIF4B
ENO2
FAM131B
FERMT3
FKBP6
GAPDH
GNMT
HNMT
HOXA3
HSP90AB1
IPO5
KCTD17
LASP1
LDHA
LGALSL
LTA4H
MAP2K3
MTNR1B
NCDN
NOL3
NUDC
NUDCD2
OR2H1
PAGE2
PAK1IP1
PEX5
PFKP
PGM1
PGM2
PHPT1
PKM
PPP1R2
PPP6R3
PRKCB
REM2
RGS14
RPSA
SARS1
SCRN2
SIAH2
STUB1
SULT1C2
TAGLN
TBL1X
TERF1
TERF2
TFRC
TOMM34
TPP1
TRIM15
TRIM16
TRIP10
TUBB
TUBB4B
TXNDC17
UCHL1
VIPR1
YWHAG
ZFP36L1
ZNF790
Entrez ID
6907
26277
HPRD ID
02183
16056
Ensembl ID
ENSG00000101849
ENSG00000092330
Uniprot IDs
O60907
B4DFJ1
Q9BSI4
PDB IDs
2XTC
2XTD
2XTE
3BQO
3BU8
5XYF
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
DNA Binding
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Transcription Repressor Complex
Negative Regulation Of Macromolecule Metabolic Process
Chromatin Organization
Nucleus
Transcription Corepressor Activity
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Structural Constituent Of Chromatin
Regulation Of Nucleobase-containing Compound Metabolic Process
Histone Deacetylase Complex
Nucleosome
Regulation Of Primary Metabolic Process
Female Courtship Behavior
Regulation Of Metabolic Process
Cellular Component Assembly
Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Thyroid Hormone Receptor Signaling Pathway
Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway
Maintenance Of Protein Location In Nucleus
Chromatin
Lung Epithelial Cell Differentiation
Lung Cell Differentiation
Chromosome, Telomeric Region
Regulation Of Macromolecule Metabolic Process
Chromatin DNA Binding
Chromatin Binding
Chromosome
Regulation Of RNA Metabolic Process
Thyroid Hormone Binding
Negative Regulation Of JNK Cascade
Shelterin Complex
Regulation Of Thyroid Hormone Receptor Signaling Pathway
Nucleosome Assembly
Nuclear Body
Negative Regulation Of Intracellular Signal Transduction
Ubiquitin-dependent Protein Catabolic Process
Maintenance Of Protein Localization In Organelle
Modification-dependent Protein Catabolic Process
Cytosol
Extracellular Exosome
Cytoplasm
ADP Metabolic Process
Purine Ribonucleotide Catabolic Process
Ribonucleoside Diphosphate Metabolic Process
Glycolytic Process
ADP Catabolic Process
Purine Nucleotide Catabolic Process
Nucleoside Phosphate Catabolic Process
Nucleoside Diphosphate Metabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Ribonucleoside Diphosphate Catabolic Process
Nucleoside Diphosphate Catabolic Process
Cadherin Binding
Pyruvate Metabolic Process
Nucleotide Catabolic Process
Carbohydrate Catabolic Process
Shelterin Complex
Organophosphate Catabolic Process
Glucose Metabolic Process
RNA-templated DNA Biosynthetic Process
Nuclear Telomere Cap Complex
Glucose Catabolic Process
Nucleobase-containing Compound Catabolic Process
Protein Localization To Chromosome, Telomeric Region
ATP Metabolic Process
Hexose Metabolic Process
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Telomere Capping
Nicotinamide Nucleotide Metabolic Process
Purine-containing Compound Metabolic Process
Generation Of Precursor Metabolites And Energy
Ficolin-1-rich Granule Lumen
Nucleobase-containing Small Molecule Metabolic Process
Monosaccharide Metabolic Process
Carbohydrate Derivative Catabolic Process
Phosphoglucomutase Activity
Nucleoside Metabolic Process
Protein Binding
Purine Ribonucleotide Metabolic Process
Calcium-dependent Phospholipid Binding
Cellular Response To Heat
Canonical Glycolysis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Ribonucleotide Metabolic Process
Glycolytic Process Through Glucose-6-phosphate
Glycolytic Process Through Fructose-6-phosphate
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