TBL1X and ARL2

Number of citations: 82 (PubMedID 36949045)
Data Source: BioGRID (two hybrid)

		TBL1X	ARL2
Name		transducin beta like 1 X-linked	ARF like GTPase 2
Structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Centrosome Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Lateral Plasma Membrane Ciliary Basal Body
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Histone Binding Identical Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Glycolytic Process Protein Folding Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly Regulation Of Aerobic Respiration
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane RAS processing
GWAS		Prostate cancer ( 23535732 ) Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		31 interacting genes: ARL2 ARL3 CDC34 CORO2A CTNNB1 DDB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I	7 interacting genes: ARL2BP LHX4 PDE6D TBCD TBL1X TBL1XR1 UNC119
Entrez ID		6907	402
HPRD ID		02183	11869
Ensembl ID		ENSG00000101849	ENSG00000213465
Uniprot IDs		O60907	P36404
PDB IDs		2XTC 2XTD 2XTE	3DOE 3DOF
GO Terms Enriched among Interactors		Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Repressor Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Transcription Corepressor Activity Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Structural Constituent Of Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Nucleosome Regulation Of Primary Metabolic Process Female Courtship Behavior Regulation Of Metabolic Process Cellular Component Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Maintenance Of Protein Location In Nucleus Chromatin Lung Epithelial Cell Differentiation Lung Cell Differentiation Chromosome, Telomeric Region Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Chromatin Binding Chromosome Regulation Of RNA Metabolic Process Thyroid Hormone Binding Negative Regulation Of JNK Cascade Shelterin Complex Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleosome Assembly Nuclear Body Negative Regulation Of Intracellular Signal Transduction Ubiquitin-dependent Protein Catabolic Process Maintenance Of Protein Localization In Organelle Modification-dependent Protein Catabolic Process	Transcription Repressor Complex Histone Deacetylase Complex Positive Regulation Of Peptidyl-tyrosine Phosphorylation Sensory Perception Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Peptidyl-tyrosine Phosphorylation Medial Motor Column Neuron Differentiation