TINF2 and DHFR2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TINF2	DHFR2
Description		TERF1 interacting nuclear factor 2	dihydrofolate reductase 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	MRNA Binding Dihydrofolate Reductase Activity Protein Binding Oxidoreductase Activity Folate Reductase Activity NADP Binding
	Biological Process	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening	One-carbon Metabolic Process Thymidine Biosynthetic Process Dihydrofolate Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Metabolism of folate and pterines
Drugs			5-Chloryl-2,4,6-quinazolinetriamine 5-[4-Tert-Butylphenylsulfanyl]-2,4-Quinazolinediamine 5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-Quinazolinediamine 5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine 5-Phenylsulfanyl-2,4-Quinazolinediamine 5-[(4-Methylphenyl)Sulfanyl]-2,4-Quinazolinediamine 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE Epigallocatechin gallate
Diseases		Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	1 interacting genes: TINF2
Entrez ID		26277	200895
HPRD ID		16056	11246
Ensembl ID		ENSG00000092330	ENSG00000178700
Uniprot IDs		B4DFJ1 Q9BSI4	B3KV46 Q86XF0
PDB IDs		3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate	Protein Localization To Chromosome, Telomeric Region Perinucleolar Chromocenter Protein Localization To Organelle Nuclear Telomere Cap Complex Shelterin Complex Telomere Capping Telomere Assembly Protein Localization To Non-motile Cilium Protein Localization To Ciliary Membrane Interneuron Migration From The Subpallium To The Cortex Neural Tube Patterning Formation Of Radial Glial Scaffolds Receptor Localization To Non-motile Cilium Left/right Axis Specification Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Non-motile Cilium Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Telomere Maintenance Via Telomere Lengthening Non-motile Cilium Assembly Ciliary Membrane Heart Looping Protein Localization To Cilium Dorsal/ventral Pattern Formation Embryonic Heart Tube Morphogenesis Positive Regulation Of Telomere Maintenance Intracellular Protein Localization Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Smoothened Signaling Pathway Determination Of Bilateral Symmetry Intercellular Bridge Determination Of Left/right Symmetry Axis Specification Telomere Maintenance Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Regulation Of Telomere Maintenance Epithelial Tube Morphogenesis Axoneme Telomere Organization Nuclear Matrix Negative Regulation Of DNA Metabolic Process Negative Regulation Of Epithelial Cell Proliferation
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