TINF2 and CTTN

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TINF2	CTTN
Gene Name		TERF1 (TRF1)-interacting nuclear factor 2	cortactin
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix	Ruffle Cytoplasm Cytoskeleton Actin Filament Coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Cortical Cytoskeleton Dendritic Spine Extracellular Vesicular Exosome Mitotic Spindle Midzone
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	Protein Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Dendritic Spine Maintenance Lamellipodium Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	36 interactors: ACD ACTA1 ACTG1 ACTR2 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 MET MYLK SDC3 SHANK2 SIRT1 SPRR2A SRC SYK TINF2 TJP1 TNK2 WASL WIPF1
Entrez ID		26277	2017
HPRD ID		16056	01268
Ensembl ID		ENSG00000092330	ENSG00000085733
Uniprot IDs		B4DFJ1 Q9BSI4	Q14247 Q53HG7
PDB IDs		3BQO 3BU8	1X69 2D1X
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Component Assembly Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Development Response To External Stimulus Developmental Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Phagocytosis Cell Communication Positive Regulation Of Organelle Organization Multicellular Organismal Development Immune Response-activating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Organelle Organization Movement Of Cell Or Subcellular Component Chemotaxis Immune Response-regulating Signaling Pathway System Development Signaling Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Response To Stimulus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Locomotion Innate Immune Response Positive Regulation Of Protein Complex Assembly Regulation Of Immune System Process Cell Morphogenesis Actin Filament Organization Positive Regulation Of Immune Response Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization
Tagcloud ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Difference) ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Intersection) ?