TBL1X and HR

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TBL1X	HR
Gene Name		transducin (beta)-like 1X-linked	hair growth associated
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Spindle Microtubule Transcriptional Repressor Complex	Nucleus Nuclear Body
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding Transcription Regulatory Region DNA Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Oxidoreductase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Proteolysis Notch Signaling Pathway Sensory Perception Of Sound Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Oxidation-reduction Process
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Orphan transporters FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization HDACs deacetylate histones Signaling by NOTCH REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: CDC34 CORO2A CTNNB1 DLX3 DNAJB4 GPS2 HDAC3 HIST1H4A HIST2H2AA3 HIST2H2BE HIST2H3C HIST2H4A HP HR KHDRBS1 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1	9 interactors: HDAC1 HDAC3 HDAC5 HMGB1 RARA RARB TBL1X TRIM27 VDR
Entrez ID		6907	55806
HPRD ID		02183	03808
Ensembl ID		ENSG00000101849	ENSG00000168453
Uniprot IDs		O60907	O43593
PDB IDs		2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Chromatin Organization Chromosome Organization Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Type I Pneumocyte Differentiation Nucleobase-containing Compound Metabolic Process Lung Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Notch Signaling Pathway DNA Methylation On Cytosine Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Telomere Maintenance Gene Expression Regulation Of Chromosome Organization Chromatin Modification Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Female Courtship Behavior DNA-templated Transcription, Initiation Organelle Organization Negative Regulation Of JNK Cascade Histone H4-K20 Demethylation Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Stress-activated MAPK Cascade Chromatin Silencing Transcription, DNA-templated Mitotic Cell Cycle RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Macromolecule Biosynthetic Process Lung Epithelial Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Histone Deacetylation Protein Deacetylation Transcription, DNA-templated Histone H4 Deacetylation RNA Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Histone H3 Deacetylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3-K9 Modification Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process DNA-templated Transcription, Initiation Chromatin Modification Positive Regulation Of Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Macromolecule Biosynthetic Process Chromatin Organization Regulation Of Apoptotic Process Regulation Of Cell Death Steroid Hormone Mediated Signaling Pathway Histone Modification Cellular Response To Stimulus Outflow Tract Septum Morphogenesis Hormone-mediated Signaling Pathway
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1	afferent bk blocker bolus bpm cardiopressor conscious drop elevations eliciting evokes ganglion hemodynamic hypotension hypotensive infusion infusions intravenous map maximum mmhg nerves opposite pressor rbf reflex rvr tachycardia unrestrained viscera
Tagcloud (Difference) ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1	afferent bk blocker bolus bpm cardiopressor conscious drop elevations eliciting evokes ganglion hemodynamic hypotension hypotensive infusion infusions intravenous map maximum mmhg nerves opposite pressor rbf reflex rvr tachycardia unrestrained viscera
Tagcloud (Intersection) ?