TINF2 and ANXA5

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TINF2	ANXA5
Description		TERF1 interacting nuclear factor 2	annexin A5
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex	Extracellular Region Cytoplasm Cytosol Focal Adhesion External Side Of Plasma Membrane Vesicle Membrane Membrane Extracellular Matrix Sarcolemma Extracellular Exosome Endothelial Microparticle
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	Phosphatidylserine Binding Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding
	Biological Process	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening	Signal Transduction Blood Coagulation Hemostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Coagulation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Platelet degranulation
Drugs			Fluocinolone acetonide L-Alpha-Glycerophosphorylserine L-thioproline K201 free base sn-glycero-3-phosphoethanolamine 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Copper
Diseases		Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Leukocyte telomere length ( 31171785) Platelet count ( 29403010)	A body shape index ( 34021172) Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Resting-state electroencephalogram vigilance ( 29703947) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	20 interacting genes: ACTG1 APP CEBPA COL10A1 COL2A1 EED EIF4G1 FDFT1 GSC2 IFNGR2 ITGB5 KDR LAMC3 LINC01554 PPP2R1B SUPT4H1 TERF1 TERF2 TERF2IP TINF2
Entrez ID		26277	308
HPRD ID		16056	00568
Ensembl ID		ENSG00000092330	ENSG00000164111
Uniprot IDs		B4DFJ1 Q9BSI4	P08758 V9HWE0
PDB IDs		3BQO 3BU8 5XYF	1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3 6K22 6K25 8GYC 8H0J 8H9Z
Enriched GO Terms of Interacting Partners?		Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Positive Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Component Organization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Chromosome Organization Chromosome, Telomeric Region Telomeric Loop Disassembly Telomere Maintenance In Response To DNA Damage Chromosome Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Multicellular Organismal-level Homeostasis Regulation Of Cell Junction Assembly Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Metabolic Process Epithelial Cell Maturation Regulation Of Organelle Organization Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Metabolic Process
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