TINF2 and CALD1

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TINF2	CALD1
Description		TERF1 interacting nuclear factor 2	caldesmon 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Myofibril Actin Cap
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	Actin Binding Protein Binding Calmodulin Binding Tropomyosin Binding Myosin Binding Cadherin Binding
	Biological Process	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening	Muscle Contraction Actin Filament Bundle Assembly
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Smooth Muscle Contraction
Drugs
Diseases		Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Leukocyte telomere length ( 31171785) Platelet count ( 29403010)	Attention deficit hyperactivity disorder symptom score ( 27663945) Glaucoma (primary open-angle) ( 33627673) Hematocrit ( 32888494) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Red blood cell count ( 32888494) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	15 interacting genes: CALM1 CALM2 CALM3 CDK1 GRB2 LBR MAPK3 POT1 PRKACA QKI RBFOX2 RNF10 SHC1 TERF1 TINF2
Entrez ID		26277	800
HPRD ID		16056	00251
Ensembl ID		ENSG00000092330	ENSG00000122786
Uniprot IDs		B4DFJ1 Q9BSI4	A0A140VKA0 E7EX44 E9PGZ1 Q05682
PDB IDs		3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Shelterin Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Chromosome Organization Spindle Microtubule Nuclear Telomere Cap Complex Sperm Midpiece Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction G2/M Transition Of Mitotic Cell Cycle Telomere Capping Cell Cycle G2/M Phase Transition Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Positive Regulation Of Telomere Maintenance Calyx Of Held Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Telomere Maintenance Via Telomerase Catalytic Complex Regulation Of Calcium-mediated Signaling Spindle Negative Regulation Of Transporter Activity Regulation Of Striated Muscle Contraction Regulation Of Chromosome Organization Calcineurin-mediated Signaling Regulation Of Heart Rate Presynaptic Cytosol Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Myelin Sheath Regulation Of Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Positive Regulation Of DNA Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Sequestering Of Calcium Ion Telomere Assembly Negative Regulation Of Calcium Ion Transmembrane Transport
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